Diversity of tRNA genes in eukaryotes.

Diversity of tRNA genes in eukaryotes. Research Abstract Details 

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Diversity of tRNA genes in eukaryotes. Abstract Text:

Jeffrey M Goodenbour,Tao Pan,

We compare the diversity of chromosomal-encoded transfer RNA (tRNA) genes from 11 eukaryotes as identified by tRNAScan-SE of their respective genomes. They include the budding and fission yeast, worm, fruit fly, fugu, chicken, dog, rat, mouse, chimp and human. The number of tRNA genes are between 170 and 570 and the number of tRNA isoacceptors range from 41 to 55. Unexpectedly, the number of tRNA genes having the same anticodon but different sequences elsewhere in the tRNA body (defined here as tRNA isodecoder genes) varies significantly (10-246). tRNA isodecoder genes allow up to 274 different tRNA species to be produced from 446 genes in humans, but only up to 51 from 275 genes in the budding yeast. The fraction of tRNA isodecoder genes among all tRNA genes increases across the phylogenetic spectrum. A large number of sequence differences in human tRNA isodecoder genes occurs in the internal promoter regions for RNA polymerase III. We also describe a systematic, ligation-based method to detect and quantify tRNA isodecoder molecules in human samples, and show differential expression of three tRNA isodecoders in six human tissues. The large number of tRNA isodecoder genes in eukaryotes suggests that tRNA function may be more diverse than previously appreciated.

Diversity of tRNA genes in eukaryotes. Publishing Authors By Initials

JM Goodenbour,T Pan,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Diversity of tRNA genes in eukaryotes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nucleic acids research

VOLUME: 34

Page Numbers: 6137-46

Journal Abbreviation: Nucleic Acids Res.

ISSN: 1362-4962

DAY: 6

MONTH: 11

YEAR: 2006

Diversity of tRNA genes in eukaryotes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 411011

Diversity of tRNA genes in eukaryotes. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Diversity of tRNA genes in eukaryotes. Information

Substance Name: RNA, Transfer

Registry Number: 9014-25-9

Grant and Affiliation Information for Diversity of tRNA genes in eukaryotes.

AFFILIATION: Department of Human Genetics, 929 East 57th street, Chicago, IL 60637, USA.

Country: England

AGENCY: United States NIGMS

GRANT: T32 GM007197

ACRONYM: GM

MEDLINETA: Nucleic Acids Res

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