Diversity of LEF/TCF action in development and disease.

Diversity of LEF/TCF action in development and disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Diversity of LEF/TCF action in development and disease. Abstract Text:

L Arce,N N Yokoyama,M L Waterman,

Lymphoid enhancer factor/T cell factor proteins (LEF/TCFs) mediate Wnt signals in the nucleus by recruiting beta-catenin and its co-activators to Wnt response elements (WREs) of target genes. This activity is important during development but its misregulation plays a role in disease such as cancer, where overactive Wnt signaling drives LEF/TCFs to transform cells. The size of the LEF/TCF family is small: approximately four members in vertebrates and one orthologous form in flies, worms and hydra. However, size belies complexity. The LEF/TCF family exhibits extensive patterns of alternative splicing, alternative promoter usage and activities of repression, as well as activation. Recent work from numerous laboratories has highlighted how this complexity has important biological consequences in development and disease.

Diversity of LEF/TCF action in development and disease. Publishing Authors By Initials

L Arce,NN Yokoyama,ML Waterman,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

PUBMED ID PMID:

MEDLINE DATE:

Diversity of LEF/TCF action in development and disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Oncogene

VOLUME: 25

Page Numbers: 7492-504

Journal Abbreviation: Oncogene

ISSN: 0950-9232

DAY: 4

MONTH: Dec

YEAR: 2006

Diversity of LEF/TCF action in development and disease. Information

Number of References: 130

LANGUAGE: eng

NlmUniqueID: 8711562

Diversity of LEF/TCF action in development and disease. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: physiology

Chemical & Substance for Abstract: Diversity of LEF/TCF action in development and disease. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Diversity of LEF/TCF action in development and disease.

AFFILIATION: Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92697-4025, USA.

Country: England

AGENCY: United States NIGMS

GRANT: GM064210

ACRONYM: GM

MEDLINETA: Oncogene

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Diversity of LEF/TCF action in development and disease Related Publications

• 6-Oxocycloartan-3beta, 16beta-diglucoside: A New Cycloartane Diglucoside from Astragalus trigonus.
• A unique DNA binding domain converts T-cell factors into strong Wnt effectors.
• Alkaloid, Lignan and Flavonoid Constituents of Haplophyllum tuberculatum from Sudan.
• An algorithm for assembly of ordered restriction maps from single DNA molecules.
• Aurantiamide Acetate in the Stem Bark of Murraya exotica.
• Biodiversity of CYP51 in trypanosomes.
• Chondrillasterol from the Tubers of Momordica cochinchinensis.
• Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET.
• Different binding modes of two flaviolin substrate molecules in cytochrome P450 158A1 (CYP158A1) compared to CYP158A2.
• Diversity of LEF/TCF action in development and disease.
• Eclampsia and peritoneal haemorrhage.
• Factors influencing organ donation decisions by African Americans: a review of the literature.
• Further Diterpenes from Stem Bark of Xylopia aethiopica1.
• IRES-mediated pathways to polysomes: nuclear versus cytoplasmic routes.
• Insertion of benzyl isocyanide into a Zr-P bond and rearrangement. Atom-economical synthesis of a phosphaalkene.
• Minocycline in staphylococcal soft-tissue infections.
• Novel properties of P450s in Streptomyces coelicolor.
• On the length of the longest exact position match in a random sequence.
• PROTECTION OF HIGHWAY WATER SUPPLIES.
• PUBLIC HEALTH ENGINEERING: Public Health Engineering Manual.
• Picropolygamain: a New Lignan from Commiphora incisa Resin1,2.
• Potential complications in myelography: I. Technical considerations.
• Relationship between spontaneous activity and metabolic rate as influenced by certain sympathomimetic compounds.
• Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.
• Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth.
• The T-matrix revisited.
• The Volatile Oil of the Oleo Resin of Aucoumea klaineana Collected in Gabon1.
• The relationship between spontaneous activity and the basal metabolic rate as influenced by certain sympathomimetic compounds.
• Three new 3-benzylbenzofuran-2-one derivatives from Homalium brachybotrys (Flacourtiaceae/Salicaceae s. l.).
• Uptake of health care services and health status of HIV-infected women diagnosed through antenatal HIV screening in Barbados, 1996-2004.