Diversity and evolution of West Nile virus in Illinois and the United States, 2002-2005.

Diversity and evolution of West Nile virus in Illinois and the United States, 2002-2005. Research Abstract Details 

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Diversity and evolution of West Nile virus in Illinois and the United States, 2002-2005. Abstract Text:

Luigi Bertolotti,Uriel Kitron,Tony L Goldberg,

Evolutionary analyses of West Nile virus (WNV) have been limited by uneven sampling across geographic regions and over time. In this study, an expanded data set of 68 WNV envelope gene sequences from the Midwest (Illinois) was created and combined with published sequences to investigate spatial and temporal structuring in the United States viral population. Results indicate an overall lack of geographic structure to WNV in the United States, supporting the notion of WNV as a rapidly expanding pathogen not significantly restricted in its spread by geographic distance. However, analyses of viral genetic diversity show a steady increase in WNV nucleotide-level diversity over time. Additionally, evolutionary rate calculations indicate that WNV has evolved at approximately 0.85 x 10(-3) substitutions/site/year, largely through neutral substitution and purifying selection. Overall, these results show WNV across the United States to be a panmictic viral population that is diversifying and evolving.

Diversity and evolution of West Nile virus in Illinois and the United States, 2002-2005. Publishing Authors By Initials

L Bertolotti,U Kitron,TL Goldberg,

For similar viruses: rna viruses: flaviviridae: flavivirus: encephalitis viruses, japanese: west nile virus research abstracts see: viruses: rna viruses: flaviviridae: flavivirus: encephalitis viruses, japanese: west nile virus research

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Diversity and evolution of West Nile virus in Illinois and the United States, 2002-2005. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Virology

VOLUME: 360

Page Numbers: 143-9

Journal Abbreviation: Virology

ISSN: 0042-6822

DAY: 20

MONTH: 11

YEAR: 2006

Diversity and evolution of West Nile virus in Illinois and the United States, 2002-2005. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 110674

Diversity and evolution of West Nile virus in Illinois and the United States, 2002-2005. Keywords Mesh Terms:

KEYWORDS: West Nile virus

MESH TERMS: genetics

Chemical & Substance for Abstract: Diversity and evolution of West Nile virus in Illinois and the United States, 2002-2005. Information

Substance Name: Viral Envelope Proteins

Registry Number: 0

Grant and Affiliation Information for Diversity and evolution of West Nile virus in Illinois and the United States, 2002-2005.

AFFILIATION: University of Illinois, Department of Pathobiology, 2001 South Lincoln Avenue, Urbana, IL 61802, USA.

Country: United States

AGENCY: United States PHS

GRANT: 0429124

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MEDLINETA: Virology

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