Diversity and diversification of light chains in myeloma: the specter of amyloidogenesis by proxy.

Diversity and diversification of light chains in myeloma: the specter of amyloidogenesis by proxy. Research Abstract Details 

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Diversity and diversification of light chains in myeloma: the specter of amyloidogenesis by proxy. Abstract Text:

Minyi Gu,Rosemary Wilton,Fred J Stevens,

BACKGROUND/AIMS: Primary amyloidosis and the cancer, multiple myeloma, are characterized by the overproduction of free antibody light chains. Approximately 10% of myeloma patients develop amyloidosis; primary amyloidosis may be thought of as the pathological analog of monoclonal gammopathy of undetermined significance. The kidney is a common site of accumulation of amyloid fibrils and is also the target of other light chain pathologies. Understanding the structural origin of these pathologies is complicated by the extreme primary structure heterogeneity of light chains. METHODS: Patterns of light chain germline gene usage in myeloma patients were compared to those found in other immune system disorders: lymphoma, leukemia, systemic lupus erythematosus and rheumatoid arthritis. RESULTS: Significant differences in apparent gene usage are found in the various diseases; several germline gene products have not been documented in myeloma patients to date. CONCLUSION: The plasma cell dyscrasias including myeloma, lymphoma, leukemia, and monoclonal gammopathy of undetermined significance are usually monoclonal diseases; however, the light chains produced are not homogeneous. Thus, the pathological risk for the patient may change during the course of the illness. Mutation rates in light chains observed during clonal diversification parallel mutations occurring in all genes in the malignant cells and could be a clinically useful biomarker.

Diversity and diversification of light chains in myeloma: the specter of amyloidogenesis by proxy. Publishing Authors By Initials

M Gu,R Wilton,FJ Stevens,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Diversity and diversification of light chains in myeloma: the specter of amyloidogenesis by proxy. Journal Published:

PUBLICATION TYPE: Review

Journal: Contributions to nephrology

VOLUME: 153

Page Numbers: 156-81

Journal Abbreviation:

ISSN: 0302-5144

DAY: 3

MONTH: 12

YEAR: 2007

Diversity and diversification of light chains in myeloma: the specter of amyloidogenesis by proxy. Information

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LANGUAGE: eng

NlmUniqueID: 7513582

Diversity and diversification of light chains in myeloma: the specter of amyloidogenesis by proxy. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: immunology

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Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Diversity and diversification of light chains in myeloma: the specter of amyloidogenesis by proxy.

AFFILIATION: Biosciences Division, Argonne National Laboratory, Argonne, IL 60439, USA.

Country: Switzerland

AGENCY: United States NIDDK

GRANT: DK43957

ACRONYM: DK

MEDLINETA: Contrib Nephrol

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