Diverse glycosylation of MUC1 and MUC2: potential significance in tumor immunity.

Diverse glycosylation of MUC1 and MUC2: potential significance in tumor immunity. Research Abstract Details 

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Diverse glycosylation of MUC1 and MUC2: potential significance in tumor immunity. Abstract Text:

T Irimura,K Denda,S i Iida,H Takeuchi,K Kato,T Irimura,K Denda,S i Iida,H Takeuchi,K Kato,

Mucins are major epithelial luminal surface proteins and function as a physical and biological barrier protecting mucous epithelia. Diverse glycosylation of mucins potentially provides a basis for tissue-specific interaction with the milieu. When mucins are associated with malignant epithelial cells, they not only protect these cells from a host environment during metastatic dissemination but also generate immunogenic epitopes which are used by the host in the detection and immunological elimination of carcinoma cells potentially depending upon their status of glycosylation. Diverse mucin structures are generated by the combination of different core peptides, of which 10 have been reported so far, multiple types of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases (pp-GalNAc-Ts), and the consequences of stepwise glycosylation events. For example, the mucin 1 (MUC1) associated with malignant cells was previously believed to exhibit unique features with a lower percentage of threonine and serine residues attached to N-acetylgalactosamine and/or without extension through core 2 structures. Some of MUC1-specific monoclonal antibodies and cytotoxic lymphocytes recognize the peptide sequences PDTR within the tandem repeat portion exposed by decreased degree of glycosylation. The specific arrangement of N-acetylgalactosamine residues is shown to be generated by a combination of pp-GalNAc-Ts with different specificities. The role of core 2 branching is somewhat confusing because well-known carcinoma-associated carbohydrate epitopes such as sialyl-Le(X), sialyl-Le(a), Le(Y), and others are often expressed when O-glycans are extended through core 2 branching. The other series of well-known carcinoma-associated carbohydrate structures are truncated O-glycans, conventionally called Tn and sialyl-Tn antigens. Interestingly, these are often found to be aligned on core polypeptides, resulting in three or more consecutive truncated O-glycans. MUC2 and other mucins, but not MUC1, have unique tandem repeats containing three or more consecutive serine or threonine residues, which potentially serve as a scaffold for trimeric Tn and sialyl-Tn epitopes. We recently found, using the MUC2 tandem repeat, that trimeric Tn is a high-affinity receptor for a calcium-type lectin expressed on the surface of histiocytic macrophages. The biosynthesis of trimeric Tn was strictly regulated by the acceptor specificity of pp-GalNAc-Ts. These results strongly suggest that variation in both glycan structures and distribution of glycans on the core polypeptides give mucins unique and diverse biological functions that play essential roles in carcinoma-host and other cellular interactions.

Diverse glycosylation of MUC1 and MUC2: potential significance in tumor immunity. Publishing Authors By Initials

T Irimura,K Denda,S Iida,H Takeuchi,K Kato,T Irimura,K Denda,S Iida,H Takeuchi,K Kato,

For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

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MEDLINE DATE:

Diverse glycosylation of MUC1 and MUC2: potential significance in tumor immunity. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of biochemistry

VOLUME: 126

Page Numbers: 975-85

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 1

MONTH: Dec

YEAR: 1999

Diverse glycosylation of MUC1 and MUC2: potential significance in tumor immunity. Information

Number of References: 87

LANGUAGE: eng

NlmUniqueID: 376600

Diverse glycosylation of MUC1 and MUC2: potential significance in tumor immunity. Keywords Mesh Terms:

KEYWORDS: Tumor Markers, Biological

MESH TERMS: metabolism

Chemical & Substance for Abstract: Diverse glycosylation of MUC1 and MUC2: potential significance in tumor immunity. Information

Substance Name: Tumor Markers, Biological

Registry Number: 0

Grant and Affiliation Information for Diverse glycosylation of MUC1 and MUC2: potential significance in tumor immunity.

AFFILIATION: Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan. irimura@mol.f.u-tokyo.ac.jp

Country: JAPAN

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MEDLINETA: J Biochem (Tokyo)

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