Diverse functions of RNase L and implications in pathology.

Diverse functions of RNase L and implications in pathology. Research Abstract Details 

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Diverse functions of RNase L and implications in pathology. Abstract Text:

Catherine Bisbal,Robert H Silverman,

The endoribonuclease L (RNase L) is the effector of the 2-5A system, a major enzymatic pathway involved in the molecular mechanism of interferons (IFNs). RNase L is a very unusual nuclease with a complex mechanism of regulation. It is a latent enzyme, expressed in nearly every mammalian cell type. Its activation requires its binding to a small oligonucleotide, 2-5A. 2-5A is a series of unique 5'-triphosphorylated oligoadenylates with 2'-5' phosphodiester bonds. By regulating viral and cellular RNA expression, RNase L plays an important role in the antiviral and antiproliferative activities of IFN and contributes to innate immunity and cell metabolism. The 2-5A/RNase L pathway is implicated in mediating apoptosis in response to viral infections and to several types of external stimuli. Several recent studies have suggested that RNase L could have a role in cancer biology and evidence of a tumor suppressor function of RNase L has emerged from studies on the genetics of hereditary prostate cancer.

Diverse functions of RNase L and implications in pathology. Publishing Authors By Initials

C Bisbal,RH Silverman,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna research

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Diverse functions of RNase L and implications in pathology. Journal Published:

PUBLICATION TYPE: Review

Journal: Biochimie

VOLUME: 89

Page Numbers: 789-98

Journal Abbreviation: Biochimie

ISSN: 0300-9084

DAY: 20

MONTH: 02

YEAR: 2007

Diverse functions of RNase L and implications in pathology. Information

Number of References: 152

LANGUAGE: eng

NlmUniqueID: 1264604

Diverse functions of RNase L and implications in pathology. Keywords Mesh Terms:

KEYWORDS: RNA

MESH TERMS: metabolism

Chemical & Substance for Abstract: Diverse functions of RNase L and implications in pathology. Information

Substance Name: pppA(2'p5'A)n-dependent ribonuclease

Registry Number: EC 3.1.26.-

Grant and Affiliation Information for Diverse functions of RNase L and implications in pathology.

AFFILIATION: IGH UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier, France. catherine.bisbal@igh.cnrs.fr

Country: France

AGENCY: United States NCI

GRANT: CA044059

ACRONYM: CA

MEDLINETA: Biochimie

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