Diurnal mood variation in outpatients with major depressive disorder: implications for DSM-V from an analysis of the Sequenced Treatment Alternatives to Relieve Depression Study data.

Diurnal mood variation in outpatients with major depressive disorder: implications for DSM-V from an analysis of the Sequenced Treatment Alternatives to Relieve Depression Study data. Research Abstract Details 

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Diurnal mood variation in outpatients with major depressive disorder: implications for DSM-V from an analysis of the Sequenced Treatment Alternatives to Relieve Depression Study data. Abstract Text:

David W Morris,A John Rush,Shailesh Jain,Maurizio Fava,Stephen R Wisniewski,G K Balasubramani,Ahsan Y Khan,Madhukar H Trivedi,David W Morris,A John Rush,Shailesh Jain,Maurizio Fava,Stephen R Wisniewski,G K Balasubramani,Ahsan Y Khan,Madhukar H Trivedi,

OBJECTIVE: Diurnal mood variation (DMV) with early morning worsening is considered a classic symptom of melancholic features in The Diagnostic and Statistical Manual of Mental Disorders (DSM) as well as The International Classification of Diseases (ICD) criteria for somatic major depressive disorder (MDD). Using the unique opportunity afforded by the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study data, we examined whether DMV with afternoon or evening worsening, in addition to classic early morning worsening, was related to other symptom constructs to determine whether the exclusive reliance on morning worsening is justified in defining melancholic features. METHOD: Baseline demographic and clinical characteristics, as well as depressive symptoms, including DMV, were evaluated in 3744 outpatients with nonpsychotic MDD enrolled in the STAR*D study. RESULTS: DMV in at least one of the time periods was reported by 22.4% (N = 837) of the sample. Only 3.3% (N = 28) of these 837 patients with DMV attributed it to environmental factors. Of the 809 participants (96.7%) with DMV unrelated to environmental events, only 31.9% (N = 258) reported morning worsening, while 19.5% (N = 158) and 48.6% (N = 393) reported afternoon and evening worsening, respectively. Minimal distinctions in demographic characteristics, clinical features, and depressive symptoms were found between participants with morning worsening and those with either afternoon or evening worsening. More importantly, other melancholic symptom features were associated with DMV regardless of time of worsening. CONCLUSION: DMV was meaningfully related to other melancholia criteria regardless of when the DMV occurred. If replicated, these findings suggest that DMV as a component of melancholic features might be expanded to include any DMV, not simply early morning worsening.

Diurnal mood variation in outpatients with major depressive disorder: implications for DSM-V from an analysis of the Sequenced Treatment Alternatives to Relieve Depression Study data. Publishing Authors By Initials

DW Morris,AJ Rush,S Jain,M Fava,SR Wisniewski,GK Balasubramani,AY Khan,MH Trivedi,DW Morris,AJ Rush,S Jain,M Fava,SR Wisniewski,GK Balasubramani,AY Khan,MH Trivedi,

For similar investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research abstracts see: investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research

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Diurnal mood variation in outpatients with major depressive disorder: implications for DSM-V from an analysis of the Sequenced Treatment Alternatives to Relieve Depression Study data. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of clinical psychiatry

VOLUME: 68

Page Numbers: 1339-47

Journal Abbreviation:

ISSN: 1555-2101

DAY: 19

MONTH: Sep

YEAR: 2007

Diurnal mood variation in outpatients with major depressive disorder: implications for DSM-V from an analysis of the Sequenced Treatment Alternatives to Relieve Depression Study data. Information

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LANGUAGE: eng

NlmUniqueID: 7801243

Diurnal mood variation in outpatients with major depressive disorder: implications for DSM-V from an analysis of the Sequenced Treatment Alternatives to Relieve Depression Study data. Keywords Mesh Terms:

KEYWORDS: Severity of Illness Index

MESH TERMS: epidemiology

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Grant and Affiliation Information for Diurnal mood variation in outpatients with major depressive disorder: implications for DSM-V from an analysis of the Sequenced Treatment Alternatives to Relieve Depression Study data.

AFFILIATION: Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9119, USA.

Country: United States

AGENCY: United States NIMH

GRANT: N01MH90003

ACRONYM: MH

MEDLINETA: J Clin Psychiatry

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