Disturbed pubertal growth in girls after acute leukaemia: a relative growth hormone insufficiency with late presentation.

Disturbed pubertal growth in girls after acute leukaemia: a relative growth hormone insufficiency with late presentation. Research Abstract Details 

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Disturbed pubertal growth in girls after acute leukaemia: a relative growth hormone insufficiency with late presentation. Abstract Text:

C Moëll,

Long-term follow-up of growth and development after acute lymphoblastic leukaemia (ALL) in childhood has previously been limited to the prepubertal period. This study describes pubertal growth, final height and the spontaneous secretion of GH in girls treated for ALL, including CNS irradiation with 24 Gy. Ten girls, treated earlier for ALL, experienced the menarche at a mean age of 12.2 years. This is significantly earlier than the mean for Swedish girls. Prepubertal growth was near normal after the end of therapy for leukaemia. Mean final height was -1.7 SD, which is 1.5 SD less than at onset and 1.0 SD less than 1 year after the end of treatment. Thirteen other girls had a blunted spontaneous secretion of GH, several years after treatment for ALL; there was no increase in GH secretion during puberty. These results suggest that girls who have been treated for ALL, including CNS irradiation, have a relative GH insufficiency. This insufficiency becomes obvious only when the girls cannot respond to the increased need for GH during the pubertal spurt.

Disturbed pubertal growth in girls after acute leukaemia: a relative growth hormone insufficiency with late presentation. Publishing Authors By Initials

C Moëll,

For similar reproductive and urinary physiology: reproduction: sexual development: puberty research abstracts see: reproductive and urinary physiology: reproduction: sexual development: puberty research

PUBMED ID PMID:

MEDLINE DATE:

Disturbed pubertal growth in girls after acute leukaemia: a relative growth hormone insufficiency with late presentation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta paediatrica Scandinavica. Supplement

VOLUME: 343

Page Numbers: 162-6

Journal Abbreviation:

ISSN: 0300-8843

DAY: 20

MONTH: 02

YEAR: 1988

Disturbed pubertal growth in girls after acute leukaemia: a relative growth hormone insufficiency with late presentation. Information

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LANGUAGE: eng

NlmUniqueID: 173166

Disturbed pubertal growth in girls after acute leukaemia: a relative growth hormone insufficiency with late presentation. Keywords Mesh Terms:

KEYWORDS: Puberty

MESH TERMS: radiation effects

Chemical & Substance for Abstract: Disturbed pubertal growth in girls after acute leukaemia: a relative growth hormone insufficiency with late presentation. Information

Substance Name: Growth Hormone

Registry Number: 9002-72-6

Grant and Affiliation Information for Disturbed pubertal growth in girls after acute leukaemia: a relative growth hormone insufficiency with late presentation.

AFFILIATION: Department of Paediatrics, University Hospital, Lund, Sweden.

Country: SWEDEN

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MEDLINETA: Acta Paediatr Scand Suppl

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