Distributions of glucuronyltransferases, GlcAT-P and GlcAT-S, and their target substrate, the HNK-1 carbohydrate epitope in the adult mouse brain with or without a targeted deletion of the GlcAT-P gene.

Distributions of glucuronyltransferases, GlcAT-P and GlcAT-S, and their target substrate, the HNK-1 carbohydrate epitope in the adult mouse brain with or without a targeted deletion of the GlcAT-P gene. Research Abstract Details 

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Distributions of glucuronyltransferases, GlcAT-P and GlcAT-S, and their target substrate, the HNK-1 carbohydrate epitope in the adult mouse brain with or without a targeted deletion of the GlcAT-P gene. Abstract Text:

Mitsuhiro Inoue,Keiko Kato,Hitomi Matsuhashi,Yasuhiko Kizuka,Toshisuke Kawasaki,Shogo Oka,Mitsuhiro Inoue,Keiko Kato,Hitomi Matsuhashi,Yasuhiko Kizuka,Toshisuke Kawasaki,Shogo Oka,Mitsuhiro Inoue,Keiko Kato,Hitomi Matsuhashi,Yasuhiko Kizuka,Toshisuke Kawasaki,Shogo Oka,

The HNK-1 carbohydrate epitope, a sulfated glucuronic acid at the non-reducing terminus of glycans, is expressed on glycoproteins and glycolipids and modulates neurite outgrowth and synaptic plasticity by affecting the adhesive and anti-adhesive properties. It is known that the HNK-1 carbohydrate is synthesized through two key enzymes, glucuronyltransferases (GlcAT-P and GlcAT-S). In the present study, we investigated the localization of GlcAT transcripts and HNK-1 carbohydrate in the adult mouse brain with or without GlcAT-P gene using in situ hybridization histochemistry and immunohistochemistry. Region-specific expression patterns of both GlcAT transcripts were observed. Strong expression of GlcAT-P and moderate expression of GlcAT-S were seen in neuronal cells of several nuclei of limbic-related regions and of the sensory system and the cerebellum. It was shown histologically that the localization of HNK-1 carbohydrate paralleled the pattern of expression of GlcAT transcripts in the brain. Additionally, the localization of HNK-1 carbohydrate was restricted partially in the brain of GlcAT-P-deficient mice, while the HNK-1 carbohydrate was widely distributed over most of the brain of wild-type mice. The present study provides a new framework for understanding the network constructed by the HNK-1 carbohydrate in the central nervous system.

Distributions of glucuronyltransferases, GlcAT-P and GlcAT-S, and their target substrate, the HNK-1 carbohydrate epitope in the adult mouse brain with or without a targeted deletion of the GlcAT-P gene. Publishing Authors By Initials

M Inoue,K Kato,H Matsuhashi,Y Kizuka,T Kawasaki,S Oka,M Inoue,K Kato,H Matsuhashi,Y Kizuka,T Kawasaki,S Oka,M Inoue,K Kato,H Matsuhashi,Y Kizuka,T Kawasaki,S Oka,

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Distributions of glucuronyltransferases, GlcAT-P and GlcAT-S, and their target substrate, the HNK-1 carbohydrate epitope in the adult mouse brain with or without a targeted deletion of the GlcAT-P gene. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Brain research

VOLUME: 1179

Page Numbers: 1-15

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 16

MONTH: 05

YEAR: 2007

Distributions of glucuronyltransferases, GlcAT-P and GlcAT-S, and their target substrate, the HNK-1 carbohydrate epitope in the adult mouse brain with or without a targeted deletion of the GlcAT-P gene. Information

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LANGUAGE: eng

NlmUniqueID: 45503

Distributions of glucuronyltransferases, GlcAT-P and GlcAT-S, and their target substrate, the HNK-1 carbohydrate epitope in the adult mouse brain with or without a targeted deletion of the GlcAT-P gene. Keywords Mesh Terms:

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AFFILIATION: Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606-8501, Japan.

Country: Netherlands

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MEDLINETA: Brain Res

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