Distributions of angiogenesis and lymphangiogenesis in gastrointestinal intramucosal tumors.

Distributions of angiogenesis and lymphangiogenesis in gastrointestinal intramucosal tumors. Research Abstract Details 

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Distributions of angiogenesis and lymphangiogenesis in gastrointestinal intramucosal tumors. Abstract Text:

Yan Gao,Wei-Xia Zhong,Dian-Bin Mu,Yin-Ping Yuan,Yu-Hua Zhang,Jin-Ming Yu,Lan-Ping Sun,Lei Wang,Yu-Hui Li,Jian-Bo Zhang,Yan Zhao,Shu-Ping Cai,Geng-Yin Zhou,

BACKGROUND: Although angiogenesis and lymphangiogenesis in gastrointestinal cancers has been investigated in many studies, their distribution characteristics in gastrointestinal intramucosal tumors have not been well addressed. METHODS: We evaluated the blood microvessel density (BMVD) and lymphatic microvessel density (LMVD) by immunostaining with monoclonal antibodies of CD34 and D2-40 in 37 patients with stomach intramucosal carcinoma and 28 patients with colorectal intramucosal neoplasia. Microvessels with endothelial cells labeled by CD34 but not by D2-40 were recognized as blood microvessels; and microvessels with endothelial cells labeled by both CD34 and D2-40 were recognized as lymphatic vessels. Furthermore, the relationships between expression of vascular endothelial growth factor (VEGF), VEGF-C, and BMVD, LMVD were investigated as well. RESULTS: The LMVD was significantly higher in peritumoral tissues than in corresponding normal tissues in gastrointestinal intramucosal tumors (20.87 versus 14.56, P = 0.003). However, there was no significant difference in the BMVD between peritumoral tissues and corresponding normal tissues (P = 0.166). The BMVD in peritumoral tissues was higher in patients with lymph node metastases than in patients without lymph nodes metastases (P = 0.047). Our results did not show significant association between VEGF, VEGF-C and BMVD, LMVD. CONCLUSIONS: Our results suggested that the increase of lymphangiogenesis seems superior to the increase of angiogenesis in gastrointestinal intramucosal tumors.

Distributions of angiogenesis and lymphangiogenesis in gastrointestinal intramucosal tumors. Publishing Authors By Initials

Y Gao,WX Zhong,DB Mu,YP Yuan,YH Zhang,JM Yu,LP Sun,L Wang,YH Li,JB Zhang,Y Zhao,SP Cai,GY Zhou,

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Distributions of angiogenesis and lymphangiogenesis in gastrointestinal intramucosal tumors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of surgical oncology

VOLUME: 15

Page Numbers: 1117-23

Journal Abbreviation: Ann. Surg. Oncol.

ISSN: 1534-4681

DAY: 18

MONTH: 01

YEAR: 2008

Distributions of angiogenesis and lymphangiogenesis in gastrointestinal intramucosal tumors. Information

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LANGUAGE: eng

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AFFILIATION: Department of Pathology, Shandong Cancer Hospital, Shandong Academy of Medical Science, 440 Jiyan Road, Jinan, Shandong, PR China.

Country: United States

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MEDLINETA: Ann Surg Oncol

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