Distribution and stability in the rat of a 76Br/125I-labelled polypeptide, epidermal growth factor.

Distribution and stability in the rat of a 76Br/125I-labelled polypeptide, epidermal growth factor. Research Abstract Details 

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Distribution and stability in the rat of a 76Br/125I-labelled polypeptide, epidermal growth factor. Abstract Text:

S Scott-Robson,J Capala,J Carlsson,P Malmborg,H Lundqvist,

A positron-emitting isotope of bromine, 76Br, with a half-life of 16.2 h, was produced using the reaction natBr(p, xn)76Kr. Labelling of mouse epidermal growth factor (EGF) with 76Br was optimized, using the chloramine-T method, obtaining a maximal radiochemical yield of 53%. In tests with receptor-rich, cultured glioma cells, [76Br]EGF and [125I]EGF bound equally well. A study of the distribution and stability of [76Br]EGF and [125I]EGF in normal rat was carried out. The distribution of both radioisotopes was similar, however, the percentage of 76Br bound to the high molecular weight fraction in the plasma, liver and kidney was greater than that of 125I.

Distribution and stability in the rat of a 76Br/125I-labelled polypeptide, epidermal growth factor. Publishing Authors By Initials

S Scott-Robson,J Capala,J Carlsson,P Malmborg,H Lundqvist,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research

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Distribution and stability in the rat of a 76Br/125I-labelled polypeptide, epidermal growth factor. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International journal of radiation applications an

VOLUME: 18

Page Numbers: 241-6

Journal Abbreviation:

ISSN: 0883-2897

DAY: 21

MONTH: 02

YEAR: 1991

Distribution and stability in the rat of a 76Br/125I-labelled polypeptide, epidermal growth factor. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8611098

Distribution and stability in the rat of a 76Br/125I-labelled polypeptide, epidermal growth factor. Keywords Mesh Terms:

KEYWORDS: Tissue Distribution

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Distribution and stability in the rat of a 76Br/125I-labelled polypeptide, epidermal growth factor. Information

Substance Name: Epidermal Growth Factor

Registry Number: 62229-50-9

Grant and Affiliation Information for Distribution and stability in the rat of a 76Br/125I-labelled polypeptide, epidermal growth factor.

AFFILIATION: Department of Radiation Sciences, Uppsala University, Sweden.

Country: UNITED STATES

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MEDLINETA: Int J Rad Appl Instrum B

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