Distinctive patterns of microRNA expression in primary muscular disorders.

Distinctive patterns of microRNA expression in primary muscular disorders. Research Abstract Details 

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Distinctive patterns of microRNA expression in primary muscular disorders. Abstract Text:

Iris Eisenberg,Alal Eran,Ichizo Nishino,Maurizio Moggio,Costanza Lamperti,Anthony A Amato,Hart G Lidov,Peter B Kang,Kathryn N North,Stella Mitrani-Rosenbaum,Kevin M Flanigan,Lori A Neely,Duncan Whitney,Alan H Beggs,Isaac S Kohane,Louis M Kunkel,Iris Eisenberg,Alal Eran,Ichizo Nishino,Maurizio Moggio,Costanza Lamperti,Anthony A Amato,Hart G Lidov,Peter B Kang,Kathryn N North,Stella Mitrani-Rosenbaum,Kevin M Flanigan,Lori A Neely,Duncan Whitney,Alan H Beggs,Isaac S Kohane,Louis M Kunkel,

The primary muscle disorders are a diverse group of diseases caused by various defective structural proteins, abnormal signaling molecules, enzymes and proteins involved in posttranslational modifications, and other mechanisms. Although there is increasing clarification of the primary aberrant cellular processes responsible for these conditions, the decisive factors involved in the secondary pathogenic cascades are still mainly obscure. Given the emerging roles of microRNAs (miRNAs) in modulation of cellular phenotypes, we searched for miRNAs regulated during the degenerative process of muscle to gain insight into the specific regulation of genes that are disrupted in pathological muscle conditions. We describe 185 miRNAs that are up- or down-regulated in 10 major muscular disorders in humans [Duchenne muscular dystrophy (DMD), Becker muscular dystrophy, facioscapulohumeral muscular dystrophy, limb-girdle muscular dystrophies types 2A and 2B, Miyoshi myopathy, nemaline myopathy, polymyositis, dermatomyositis, and inclusion body myositis]. Although five miRNAs were found to be consistently regulated in almost all samples analyzed, pointing to possible involvement of a common regulatory mechanism, others were dysregulated only in one disease and not at all in the other disorders. Functional correlation between the predicted targets of these miRNAs and mRNA expression demonstrated tight posttranscriptional regulation at the mRNA level in DMD and Miyoshi myopathy. Together with direct mRNA-miRNA predicted interactions demonstrated in DMD, some of which are involved in known secondary response functions and others that are involved in muscle regeneration, these findings suggest an important role of miRNAs in specific physiological pathways underlying the disease pathology.

Distinctive patterns of microRNA expression in primary muscular disorders. Publishing Authors By Initials

I Eisenberg,A Eran,I Nishino,M Moggio,C Lamperti,AA Amato,HG Lidov,PB Kang,KN North,S Mitrani-Rosenbaum,KM Flanigan,LA Neely,D Whitney,AH Beggs,IS Kohane,LM Kunkel,I Eisenberg,A Eran,I Nishino,M Moggio,C Lamperti,AA Amato,HG Lidov,PB Kang,KN North,S Mitrani-Rosenbaum,KM Flanigan,LA Neely,D Whitney,AH Beggs,IS Kohane,LM Kunkel,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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Distinctive patterns of microRNA expression in primary muscular disorders. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 17016-21

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 17

MONTH: 10

YEAR: 2007

Distinctive patterns of microRNA expression in primary muscular disorders. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Distinctive patterns of microRNA expression in primary muscular disorders. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: metabolism

Chemical & Substance for Abstract: Distinctive patterns of microRNA expression in primary muscular disorders. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for Distinctive patterns of microRNA expression in primary muscular disorders.

AFFILIATION: Howard Hughes Medical Institute, Program in Genomics, Division of Genetics, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: R01 AR 044345

ACRONYM: AR

MEDLINETA: Proc Natl Acad Sci U S A

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