Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability.

Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability. Research Abstract Details 

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Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability. Abstract Text:

Veronica A Alvarez,Dennis A Ridenour,Bernardo L Sabatini,

NMDA-type glutamate receptors (NMDARs) play a central role in the rapid regulation of synaptic transmission, but their contribution to the long-term stabilization of glutamatergic synapses is unknown. We find that, in hippocampal pyramidal neurons in rat organotypic slices, pharmacological blockade of NMDARs does not affect synapse formation and dendritic spine growth but does increase the motility of spines. Physical loss of synaptic NMDARs induced by RNA interference against the NR1 subunit of the receptor also increases the motility of spines. Furthermore, knock-down of NMDARs, but not their pharmacological block, destabilizes spine structure and over time leads to loss of spines and excitatory synapses. Maintenance of normal spine density requires the coexpression of two specific splice isoforms of the NR1 subunit that contain the C-terminal C2 cassette. Thus, although ionotropic properties of NMDARs induce synaptic plasticity, it is the physical interactions of the C-tail of the receptor that mediate the long-term stabilization of synapses and spines.

Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability. Publishing Authors By Initials

VA Alvarez,DA Ridenour,BL Sabatini,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 7365-76

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 11

MONTH: Jul

YEAR: 2007

Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability. Information

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LANGUAGE: eng

NlmUniqueID: 8102140

Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: physiology

Chemical & Substance for Abstract: Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability. Information

Substance Name: Receptors, N-Methyl-D-Aspartate

Registry Number: 0

Grant and Affiliation Information for Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability.

AFFILIATION: Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Country: United States

AGENCY: United States NINDS

GRANT: 5T32 NS07484

ACRONYM: NS

MEDLINETA: J Neurosci

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