Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors.

Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors. Research Abstract Details 

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Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors. Abstract Text:

L St Pierre,H Fischer,D J Adams,M Schenning,N Lavidis,J de Jersey,P P Masci,M F Lavin,L St Pierre,H Fischer,D J Adams,M Schenning,N Lavidis,J de Jersey,P P Masci,M F Lavin,

Envenomation from Australian elapid snakes results in a myriad of neurological effects due to post-synaptic neurotoxins that bind and inhibit nicotinic acetylcholine receptors (nAChRs) of neurons and muscle fibres. However, despite the significant physiological effects of these toxins, they have remained largely undercharacterised at the molecular level. This study describes the identification and comparative analysis of multiple neurotoxin isoforms from ten Australian snakes, including functional characterisation of two of these isoforms, Os SNTX-1 from Oxyuranus scutellatus and the more potent Pt LNTX-1 from Pseudonaja textilis. Electrophysiological recordings from adrenal chromaffin cells demonstrate that both neurotoxins act as competitive antagonists of nAChRs in a concentration-dependent manner. Their effects upon spontaneous and nerve-evoked membrane responses at the amphibian neuromuscular junction provide further evidence that both toxins bind muscle nAChRs in an irreversible manner. This study represents one of the most comprehensive descriptions to date of the sequences and activity of individual Australian elapid neurotoxins.

Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors. Publishing Authors By Initials

L St Pierre,H Fischer,DJ Adams,M Schenning,N Lavidis,J de Jersey,PP Masci,MF Lavin,L St Pierre,H Fischer,DJ Adams,M Schenning,N Lavidis,J de Jersey,PP Masci,MF Lavin,

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Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cellular and molecular life sciences : CMLS

VOLUME: 64

Page Numbers: 2829-40

Journal Abbreviation: Cell. Mol. Life Sci.

ISSN: 1420-682X

DAY: 23

MONTH: Nov

YEAR: 2007

Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors. Information

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LANGUAGE: eng

NlmUniqueID: 9705402

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Grant and Affiliation Information for Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors.

AFFILIATION: The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, P.O. Box Royal Brisbane Hospital, Herston, Brisbane, 4029, Australia.

Country: Switzerland

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MEDLINETA: Cell Mol Life Sci

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