Dissociated representations of irritation and valence in human primary olfactory cortex.

Dissociated representations of irritation and valence in human primary olfactory cortex. Research Abstract Details 

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Dissociated representations of irritation and valence in human primary olfactory cortex. Abstract Text:

C Zelano,J Montag,B Johnson,R Khan,N Sobel,

Irritation and negative valence are closely associated in perception. However, these perceptual aspects can be dissociated in olfaction where irritation can accompany both pleasant and unpleasant odorants. Whereas the sensation of odor reflects transduction at olfactory receptors, irritation reflects concurrent transduction of the odorant at trigeminal receptors. Thus a stimulus can be either a pure olfactant activating the olfactory receptors only or a bimodal odorant activating both types of receptors. Using event-related functional magnetic resonance imaging and a 2 x 2 experimental design contrasting odorant valence (pleasant/unpleasant) and odorant type (pure olfactant/bimodal) we found activity in piriform cortex to be associated with valence, and not type, of odors. In contrast, activity in the olfactory tubercle was associated with type, and not valence, of odors. Importantly, this was found when perceived intensity was held equal across odorants. These findings suggest that dissociable neural substrates subserve the encoding of irritation and valence in olfaction.

Dissociated representations of irritation and valence in human primary olfactory cortex. Publishing Authors By Initials

C Zelano,J Montag,B Johnson,R Khan,N Sobel,

For similar nervous system: central nervous system: brain: prosencephalon: diencephalon: thalamus research abstracts see: nervous system: central nervous system: brain: prosencephalon: diencephalon: thalamus research

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Dissociated representations of irritation and valence in human primary olfactory cortex. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of neurophysiology

VOLUME: 97

Page Numbers: 1969-76

Journal Abbreviation: J. Neurophysiol.

ISSN: 0022-3077

DAY: 10

MONTH: 01

YEAR: 2007

Dissociated representations of irritation and valence in human primary olfactory cortex. Information

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LANGUAGE: eng

NlmUniqueID: 375404

Dissociated representations of irritation and valence in human primary olfactory cortex. Keywords Mesh Terms:

KEYWORDS: Thalamus

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Dissociated representations of irritation and valence in human primary olfactory cortex. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Dissociated representations of irritation and valence in human primary olfactory cortex.

AFFILIATION: Program in Biophysics, University of California, Berkeley, 3210 Tolman Hall MC 1650, Berkeley, CA 94702, USA. zelano@socrates.berkeley.edu

Country: United States

AGENCY: United States NIDCD

GRANT: DC-006915

ACRONYM: DC

MEDLINETA: J Neurophysiol

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