Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21.

Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21. Abstract Text:

Michael R Garrett,William T Gunning,Tracy Radecki,Arti Richard,

Previously, we conducted a genome scan on a population derived from the Dahl salt-sensitive hypertensive (S) and the spontaneously hypertensive rat (SHR) using urinary albumin excretion (UAE) as our primary measure of renal function. We identified 10 quantitative trait loci (QTL) linked to several renal and/or cardiovascular traits. In particular, linkage and subsequent congenic strain analysis demonstrated that the loci on chromosome 2 had a large and significant effect on UAE compared with the S rat. The present work sought to characterize the chromosome 2 congenic strain [S.SHR] by conducting a time-course analysis (week 4-20), including evaluating additional renal parameters, histology, electron microscopy, and gene expression/ pathway analysis. Throughout the time course the congenic strain consistently maintained a threefold reduction in UAE compared with S rats and was supported by the histological findings of significantly reduced glomerular, tubular and interstitial changes. Gene expression/pathway analysis performed at week 4, 12, and 20 revealed that pathways involved in cellular assembly and organization, cellular movement, and immune response were controlled differently between the S and congenic. When all the data are considered, the chromosome 2 congenic appears to attenuate renal damage primarily through an altered fibrotic response. Recombinant progeny testing was employed to reduce the QTL to approximately 1.5 cM containing several interesting candidate genes. The concordance of this rat QTL with renal disease loci on human chromosome 1q21 demonstrate that elucidating the causative gene and mechanism of the rat QTL may be of particular importance for understanding kidney disease in humans.

Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21. Publishing Authors By Initials

MR Garrett,WT Gunning,T Radecki,A Richard,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

PUBMED ID PMID:

MEDLINE DATE:

Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Physiological genomics

VOLUME: 30

Page Numbers: 322-34

Journal Abbreviation: Physiol. Genomics

ISSN: 1531-2267

DAY: 15

MONTH: 05

YEAR: 2007

Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9815683

Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21.

AFFILIATION: Department of Physiology, Pharmacology, Metabolism and Cardiovascular Sciences, University of Toledo, Health Science Campus, Toledo, Ohio, USA. mgarrett@mcw.edu

Country: United States

AGENCY: United States NHLBI

GRANT: R01-HL-066998

ACRONYM: HL

MEDLINETA: Physiol Genomics

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21 Related Publications

• A novel GJA 1 mutation in oculo-dento-digital dysplasia with curly hair and hyperkeratosis.
• A simple method to determine kinetic deuterium isotope effects provides evidence that proton transfer to carbon proceeds over and not through the reaction barrier.
• A transition state analog for phosphate diester cleavage catalyzed by a small enzyme-like metal ion complex.
• An optimised methodology for the neurobehavioural assessment in rodents.
• Claisen-type addition of glycine to a pyridoxal iminium ion in water.
• Coming out to care: caregivers of gay and lesbian seniors in Canada.
• Covalent catalysis by pyridoxal: evaluation of the effect of the cofactor on the carbon acidity of glycine.
• Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21.
• Energy expenditure: a critical determinant of energy balance with key hypothalamic controls.
• Enzymatic catalysis of proton transfer at carbon: activation of triosephosphate isomerase by phosphite dianion.
• Foamy Virus Vectors Expressing Anti-HIV Transgenes Efficiently Block HIV-1 Replication.
• Identification in the mould Hypocrea jecorina of a gene encoding an NADP(+): d-xylose dehydrogenase.
• Improvement of VO2max by cardiac output and oxygen extraction adaptation during intermittent versus continuous endurance training.
• Inhibition of humic substances mediated photooxygenation of furfuryl alcohol by 2,4,6-trimethylphenol. Evidence for reactivity of the phenol with humic triplet excited states.
• Malignant proliferating pilar tumors arising in KID syndrome: a report of two patients.
• Phenotypic Correction of alpha-Sarcoglycan Deficiency by Intra-arterial Injection of a Muscle-specific Serotype 1 rAAV Vector.
• Practical identifiability of photophysical parameters in photodynamic therapy.
• Product deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediate.
• Rational design of transition-state analogues as potent enzyme inhibitors with therapeutic applications.
• Some major mycotoxins and their mycotoxicoses-An overview.
• Targeting the RNA-binding protein Sam68 as a treatment for cancer?
• The motivational interview.
• The motivational interview: In practice.
• Topical tacrolimus treatment for chronic dermatitis of the ear.
• Use of local area facilities for involvement in physical activity in Canada: insights for developing environmental and policy interventions.
• When does an intermediate become a transition state? Degenerate isomerization without competing racemization during solvolysis of (S)-1-(3-nitrophenyl)ethyl tosylate.
• Winning the battle for standardization. The U.S. Army Medical Department examines the EMR to develop a standardized process for medication reconciliation documentation.
• [Carbon dioxide laser therapy for anogenital warts in children.]
• [The lessons of Cleopatra or reflections on conter-transfer and borderlines.]
• [The prevalence of bilateral malignant uveal melanoma]