Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative.

Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Research Abstract Details 

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Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Abstract Text:

Alfredo A Molinolo,Stephen M Hewitt,Panomwat Amornphimoltham,Somboon Keelawat,Samraeung Rangdaeng,Abelardo ,Ana R Raimondi,Rafael Jufe, Itoiz,Yan Gao,Dhananjaya Saranath,George S Kaleebi,George H Yoo,Lee Leak,Ernest M Myers,Satoru Shintani,David Wong,H Davis Massey,W Andrew Yeudall,Fulvio Lonardo,John Ensley,J Silvio Gutkind,

PURPOSE: As an approach to evaluate the expression pattern and status of activation of signaling pathways in clinical specimens from head and neck squamous cell carcinoma (HNSCC) patients, we established the Head and Neck Cancer Tissue Array Initiative, an international consortium aimed at developing a high-density HNSCC tissue microarray, with a high representation of oral squamous cell carcinoma. EXPERIMENTAL DESIGN: These tissue arrays were constructed by acquiring cylindrical biopsies from multiple individual tumor tissues and transferring them into tissue microarray blocks. From a total of 1,300 cases, 547 cores, including controls, were selected and used to build the array. RESULTS: Emerging information by the use of phosphospecific antibodies detecting the activated state of signaling molecules indicates that the Akt-mammalian target of rapamycin (mTOR) pathway is frequently activated in HNSCC, but independently from the activation of epidermal growth factor receptor or the detection of mutant p53. Indeed, we identified a large group of tissue samples displaying active Akt and mTOR in the absence of epidermal growth factor receptor activation. Furthermore, we have also identified a small subgroup of patients in which the mTOR pathway is activated but not Akt, suggesting the existence of an Akt-independent signaling route stimulating mTOR. CONCLUSIONS: These findings provide important information about the nature of the dysregulated signaling networks in HNSCC and may also provide the rationale for the future development of novel mechanism-based therapies for HNSCC patients.

Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Publishing Authors By Initials

AA Molinolo,SM Hewitt,P Amornphimoltham,S Keelawat,S Rangdaeng,A ,AR Raimondi,R Jufe,M Itoiz,Y Gao,D Saranath,GS Kaleebi,GH Yoo,L Leak,EM Myers,S Shintani,D Wong,HD Massey,WA Yeudall,F Lonardo,J Ensley,JS Gutkind,

For similar proteins: neoplasm proteins: tumor suppressor proteins research abstracts see: proteins: neoplasm proteins: tumor suppressor proteins research

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Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Clinical cancer research : an official journal of

VOLUME: 13

Page Numbers: 4964-73

Journal Abbreviation: Clin. Cancer Res.

ISSN: 1078-0432

DAY: 1

MONTH: Sep

YEAR: 2007

Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Information

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LANGUAGE: eng

NlmUniqueID: 9502500

Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Proteins

MESH TERMS: analysis

Chemical & Substance for Abstract: Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Information

Substance Name: Proto-Oncogene Proteins c-akt

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative.

AFFILIATION: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4330, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: R01-DE15970

ACRONYM: DE

MEDLINETA: Clin Cancer Res

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