Disruption of primary motor cortex before learning impairs memory of movement dynamics.

Disruption of primary motor cortex before learning impairs memory of movement dynamics. Research Abstract Details 

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Disruption of primary motor cortex before learning impairs memory of movement dynamics. Abstract Text:

Andrew G Richardson,Simon A Overduin,Antoni ,Camillo Padoa-Schioppa,Alvaro Pascual-Leone,Emilio Bizzi,Daniel Z Press,

Although multiple lines of evidence implicate the primary motor cortex (M1) in motor learning, the precise role of M1 in the adaptation to novel movement dynamics and in the subsequent consolidation of a memory of those dynamics remains unclear. Here we used repetitive transcranial magnetic stimulation (rTMS) to dissociate the contribution of M1 to these distinct aspects of motor learning. Subjects performed reaching movements in velocity-dependent force fields over three epochs: a null-field baseline epoch, a clockwise-field learning epoch (15 min after the baseline epoch), and a clockwise-field retest epoch (24 h after the learning epoch). Half of the subjects received 15 min of 1 Hz rTMS to M1 between the baseline and learning epochs. Subjects given rTMS performed identically to control subjects during the learning epoch. However, control subjects performed with significantly less error than rTMS subjects in the retest epoch on the following day. These results suggest that M1 is not critical to the network supporting motor adaptation per se but that, within this network, M1 may be important for initiating the development of long-term motor memories.

Disruption of primary motor cortex before learning impairs memory of movement dynamics. Publishing Authors By Initials

AG Richardson,SA Overduin,A ,C Padoa-Schioppa,A Pascual-Leone,E Bizzi,DZ Press,

For similar psychological phenomena and processes: psychomotor performance research abstracts see: psychological phenomena and processes: psychomotor performance research

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Disruption of primary motor cortex before learning impairs memory of movement dynamics. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of neuroscience : the official journal

VOLUME: 26

Page Numbers: 12466-70

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 29

MONTH: Nov

YEAR: 2006

Disruption of primary motor cortex before learning impairs memory of movement dynamics. Information

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LANGUAGE: eng

NlmUniqueID: 8102140

Disruption of primary motor cortex before learning impairs memory of movement dynamics. Keywords Mesh Terms:

KEYWORDS: Psychomotor Performance

MESH TERMS: physiology

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Grant and Affiliation Information for Disruption of primary motor cortex before learning impairs memory of movement dynamics.

AFFILIATION: Division of Health Sciences and Technology, Massachusetts Institute of Technology and Harvard Medical School, Cambridge, Massachusetts 02142, USA.

Country: United States

AGENCY: United States NIMH

GRANT: K23-MH65434

ACRONYM: MH

MEDLINETA: J Neurosci

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