Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation.

Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Research Abstract Details 

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Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Abstract Text:

Aimin Jiang,Ona Bloom,Satoru Ono,Weiguo Cui,Juli Unternaehrer,Shan Jiang,J Andrew Whitney,John Connolly,Jacques Banchereau,Ira Mellman,Aimin Jiang,Ona Bloom,Satoru Ono,Weiguo Cui,Juli Unternaehrer,Shan Jiang,J Andrew Whitney,John Connolly,Jacques Banchereau,Ira Mellman,

The maturation of dendritic cells (DCs) after exposure to microbial products or inflammatory mediators plays a critical role in initiating the immune response. We found that maturation can also occur under steady-state conditions, triggered by alterations in E-cadherin-mediated DC-DC adhesion. Selective disruption of these interactions induced the typical features of DC maturation including the upregulation of costimulatory molecules, MHC class II, and chemokine receptors. These events were triggered at least in part by activation of the beta-catenin pathway. However, unlike maturation induced by microbial products, E-cadherin-stimulated DCs failed to release immunostimulatory cytokines, exhibiting an entirely different transcriptional profile. As a result, E-cadherin-stimulated DCs elicited an entirely different T cell response in vivo, generating T cells with a regulatory as opposed to an effector phenotype. These DCs induced tolerance in vivo and may thus contribute to the elusive steady-state "tolerogenic DCs."

Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Publishing Authors By Initials

A Jiang,O Bloom,S Ono,W Cui,J Unternaehrer,S Jiang,JA Whitney,J Connolly,J Banchereau,I Mellman,A Jiang,O Bloom,S Ono,W Cui,J Unternaehrer,S Jiang,JA Whitney,J Connolly,J Banchereau,I Mellman,

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Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Immunity

VOLUME: 27

Page Numbers: 610-24

Journal Abbreviation: Immunity

ISSN: 1074-7613

DAY: 11

MONTH: 10

YEAR: 2007

Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Information

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LANGUAGE: eng

NlmUniqueID: 9432918

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Grant and Affiliation Information for Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation.

AFFILIATION: Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, PO Box 208002, New Haven, CT 06520, USA.

Country: United States

AGENCY: United States NIAID

GRANT: U19AI057234

ACRONYM: AI

MEDLINETA: Immunity

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