Disruption in Th1/Th2 immune response in young adult smokers.

Disruption in Th1/Th2 immune response in young adult smokers. Research Abstract Details 

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Disruption in Th1/Th2 immune response in young adult smokers. Abstract Text:

Courtney A Whetzel,Elizabeth J Corwin,Laura Cousino Klein,

Interferon (IFN)-gamma and IL-10 cytokines, measures of Th1 and Th2 immunity, were examined in 20 healthy nonsmokers (12 males, 8 females) and 19 smokers (11 males, 8 females), aged 19-41 years (23.46+/-0.82 years). Nonsmokers came to the laboratory once; smokers came to the laboratory after ad lib smoking and following 24-h smoking abstinence. Salivary cotinine and expired CO confirmed smoking status. Plasma was collected at the end of each lab session and assayed for peripheral IFN-gamma and IL-10 levels. Among smokers, peripheral IFN-gamma, IL-10, or IFN-gamma/IL-10 ratio levels did not change in response to 24-h smoking abstinence. IFN-gamma levels and IFN-gamma/IL-10 ratios were higher among female smokers while smoking and following 24-h abstinence compared to male smokers in both conditions and compared to male and female nonsmokers. There was no sex or smoking status difference in IL-10 levels. Results suggest that cigarette smoking may have at least short-term damaging effects on the body's normal immune balance, particularly for women.

Disruption in Th1/Th2 immune response in young adult smokers. Publishing Authors By Initials

CA Whetzel,EJ Corwin,LC Klein,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, helper-inducer: th2 cells research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, helper-inducer: th2 cells research

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MEDLINE DATE:

Disruption in Th1/Th2 immune response in young adult smokers. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Addictive behaviors

VOLUME: 32

Page Numbers: 1-8

Journal Abbreviation:

ISSN: 0306-4603

DAY: 27

MONTH: 04

YEAR: 2006

Disruption in Th1/Th2 immune response in young adult smokers. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603486

Disruption in Th1/Th2 immune response in young adult smokers. Keywords Mesh Terms:

KEYWORDS: Th2 Cells

MESH TERMS: immunology

Chemical & Substance for Abstract: Disruption in Th1/Th2 immune response in young adult smokers. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Disruption in Th1/Th2 immune response in young adult smokers.

AFFILIATION: Department of Biobehavioral Health, 315 East Health and Human Development Building, The Pennsylvania State University, University Park, PA 16802, USA.

Country: England

AGENCY: United States NCRR

GRANT: M01-RR-10732

ACRONYM: RR

MEDLINETA: Addict Behav

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