Disrupting the establishment of polarizing activity by teratogen exposure.

Disrupting the establishment of polarizing activity by teratogen exposure. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Disrupting the establishment of polarizing activity by teratogen exposure. Abstract Text:

S M Bell,C M Schreiner,W J Scott,

Between days 9.5 and 10, the forelimb buds of developing murine embryos progress from stage 1 which are just beginning to express shh and whose posterior mesoderm has only weak polarizing activity to stage 2 limbs with a distinguishable shh expression domain and full polarizing activity. We find that exposure on day 9.5 to teratogens that induce the loss of posterior skeletal elements disrupts the polarizing activity of the stage 2 postaxial mesoderm and polarizing activity is not subsequently restored. The ontogeny of expression of the mesodermal markers shh, ptc, bmp2, and hoxd-12 and 13, as well as the ectodermal markers wnt7a, fgf4, fgf8, cx43, and p21 occurred normally in day 9.5 teratogen-exposed limb buds. At stage 3, the treated limb apical ectodermal ridge usually possessed no detectable abnormalities, but with continued outgrowth postaxial deficiencies became evident. Recombining control, stage matched limb bud ectoderm with treated mesoderm prior to ZPA grafting restored the duplicating activity of treated ZPA tissue. We conclude that in addition to shh an early ectoderm-dependent signal is required for the establishment of the mouse ZPA and that this factor is dependent on the posterior ectoderm.

Disrupting the establishment of polarizing activity by teratogen exposure. Publishing Authors By Initials

SM Bell,CM Schreiner,WJ Scott,

For similar peptides: intercellular signaling peptides and proteins: wnt proteins research abstracts see: peptides: intercellular signaling peptides and proteins: wnt proteins research

PUBMED ID PMID:

MEDLINE DATE:

Disrupting the establishment of polarizing activity by teratogen exposure. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Mechanisms of development

VOLUME: 88

Page Numbers: 147-57

Journal Abbreviation: Mech. Dev.

ISSN: 0925-4773

DAY: 19

MONTH: Nov

YEAR: 1999

Disrupting the establishment of polarizing activity by teratogen exposure. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9101218

Disrupting the establishment of polarizing activity by teratogen exposure. Keywords Mesh Terms:

KEYWORDS: Wnt Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: Disrupting the establishment of polarizing activity by teratogen exposure. Information

Substance Name: Acetazolamide

Registry Number: 59-66-5

Grant and Affiliation Information for Disrupting the establishment of polarizing activity by teratogen exposure.

AFFILIATION: Children's Hospital Research Foundation, Division of Developmental Biology, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. sheila.bell@chmcc.org

Country: IRELAND

AGENCY: United States NIEHS

GRANT: ES 07051

ACRONYM: ES

MEDLINETA: Mech Dev

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Disrupting the establishment of polarizing activity by teratogen exposure Related Publications

• A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory.
• Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations.
• Analysis of the role of CovR and CovS in the dissemination of Streptococcus pyogenes in invasive skin disease.
• Antimicrobial activity of an abiotic host defense peptide mimic.
• Assessment of lumiracoxib bioavailability from targeted sites in the human intestine using remotely activated capsules and gamma scintigraphy.
• Cholesterol surrogates: a comparison of cholesterol and 16:0 ceramide in POPC bilayers.
• Combined Monte Carlo and molecular dynamics simulation of hydrated 18:0 sphingomyelin-cholesterol lipid bilayers.
• Comparison and Evaluation of PET/CT Image Registration.
• CovR activation of the dipeptide permease promoter (PdppA) in Group A Streptococcus.
• Disrupting the establishment of polarizing activity by teratogen exposure.
• Enhancing milk quality and yield in the dairy cow and buffalo by feeding protected nutrient supplements.
• Featural and configural face processing in adults and infants: a behavioral and electrophysiological investigation.
• Fine-tuning our knowledge of the anaerobic route to cobalamin (vitamin B12).
• Genetically engineered synthesis and structural characterization of cobalt-precorrin 5A and -5B, two new intermediates on the anaerobic pathway to vitamin B12: definition of the roles of the CbiF and CbiG enzymes.
• Genomic imprinting in plants.
• Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family.
• Hypersensitivity syndromes; erythema multiforme, erythema nodosum, urticaria.
• Lateral organization in lipid-cholesterol mixed bilayers.
• Mosquitoes do senesce: departure from the paradigm of constant mortality.
• Moyamoya syndrome associated with cocaine abuse. Case report.
• Novel applications of multichannel spectroscopy in pharmaceutical analysis.
• Novel pathways associated with quinone-induced stress in breast cancer cells.
• Relationships between fertility, peak milk yields and lactational persistency in dairy cows.
• Role of mRNA stability in growth phase regulation of gene expression in the group A streptococcus.
• Rumen protected conjugated linoleic acid (CLA) methyl esters decrease milk fat and increase CLA concentration in goat milk.
• Spatial and temporal patterns in the recovery of Aedes aegypti (Diptera: Culicidae) populations after insecticide treatment.
• The Role of A-Kinase Anchoring Proteins in cAMP-Mediated Signal Transduction Pathways.
• The evolution of walking-related outcomes over the first 12 weeks of rehabilitation for incomplete traumatic spinal cord injury: the multicenter randomized Spinal Cord Injury Locomotor Trial.
• Unraveling the regulatory network in Streptococcus pyogenes: the global response regulator CovR represses rivR directly.
• Urea transport in bacteria: acid acclimation by gastric Helicobacter spp.