Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling.

Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling. Abstract Text:

Stephen J Turner,Elvia Olivas,Astrid Gutierrez,Gabriela Diaz,Peter C Doherty,

Recent studies indicate that IFN-gamma may influence both the expansion and the trafficking of virus-specific CD8+ CTL, though the effects are not necessarily consistent for different models of viral and bacterial disease. Influenza A virus infection of mice deficient for IFN-gamma (IFN-gamma(-/-)) or deficient for the IFN-gamma receptor 1 (IFNGR1(-/-)) was, when compared with the wild-type (WT) B6 controls, associated with increased Ag-specific CD8+ T cell counts in the spleen and mediastinal lymph nodes. At the same time, fewer of these CTL effectors were found in the bronchoalveolar lavage population recovered from the IFN-gamma(-/-) mice. Comparable effects were observed for WT mice treated with a neutralizing IFN-gamma-specific mAb. Transfer of WT memory Thy1.1(+) CD8+ populations into Thy1.2+ B6 IFN-gamma(-/-) or IFNGR1(-/-) mice followed by intranasal virus challenge demonstrated both that IFN-gamma produced by the host was important for the regulation of Ag-specific CTL numbers and that IFN-gamma was likely to act directly on the T cells themselves. In addition, the prevalence of CTLs undergoing apoptosis in spleen was lower when measured directly ex vivo for IFN-gamma(-/-) vs WT B6 mice. The present analysis is the first comprehensive demonstration that IFN-gamma signaling can differentially regulate both Ag-specific CTL homeostasis in secondary lymphoid organs and trafficking to a site of virus-induced pathology.

Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling. Publishing Authors By Initials

SJ Turner,E Olivas,A Gutierrez,G Diaz,PC Doherty,

For similar tissues: lymphoid tissue: spleen research abstracts see: tissues: lymphoid tissue: spleen research

PUBMED ID PMID:

MEDLINE DATE:

Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 178

Page Numbers: 7616-22

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Jun

YEAR: 2007

Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling. Keywords Mesh Terms:

KEYWORDS: Spleen

MESH TERMS: immunology

Chemical & Substance for Abstract: Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling.

AFFILIATION: Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. sjturn@unimelb.edu.au

Country: United States

AGENCY: United States NIAID

GRANT: AI 29579

ACRONYM: AI

MEDLINETA: J Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling Related Publications

• A long-acting, mono-PEGylated human growth hormone analog is a potent stimulator of weight gain and bone growth in hypophysectomized rats.
• A randomized, placebo-controlled trial of preoperative oral pregabalin for postoperative pain relief after minor gynecological surgery.
• Acute alcohol intake impairs lung inflammation by changing pro- and anti-inflammatory mediator balance.
• Admission of error?
• Bioterrorism and biologic warfare.
• CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver.
• Concurrent sexual partnerships among men in the United States.
• Correction of the peripheral spatiotemporal response pattern: a potential new signal-processing strategy.
• Could we care for Amillia in rural Australia?
• Creatine monohydrate and conjugated linoleic Acid improve strength and body composition following resistance exercise in older adults.
• Development of a standardized medication assistant curriculum.
• Differential Affects of Interventions on Gait and Balance among People with Peripheral Neuropathy: 1655: Board #145 May 30 2:00 PM - 3:30 PM.
• Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling.
• Effects of ketamine and magnesium on the minimum alveolar concentration of isoflurane in goats.
• Establishing priorities for national communicable disease surveillance.
• Fungous infections of the skin and scalp; a new approach to their treatment.
• Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses.
• Level VI lymph node dissection for papillary thyroid cancer.
• Location rather than CD62L phenotype is critical in the early establishment of influenza-specific CD8+ T cell memory.
• Nonhomologous end-joining in bacteria: a microbial perspective.
• Oral and Maxillofacial Injuries Experienced in Support of Operation Iraqi Freedom I and II.
• Screening pesticides for neuropathogenicity.
• Sweat And Core Temperature Responses In Professional Women's Tennis During Tournament Play In The Heat: 575: May 30 1:45 PM 2:00 PM.
• The control of attention to faces.
• The effect of prior bisphosphonate exposure on the treatment response to teriparatide in clinical practice.
• The latest in trauma nursing.
• Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity.
• Use of glass irrigator for anterior chamber.
• Validation of a self-report instrument for assessment of hallux valgus.
• [Assessing the prognosis in patients with chronic obstructive pulmonary disease]