Displacement of brain regions in preterm infants with non-synostotic dolichocephaly investigated by MRI.

Displacement of brain regions in preterm infants with non-synostotic dolichocephaly investigated by MRI. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Displacement of brain regions in preterm infants with non-synostotic dolichocephaly investigated by MRI. Abstract Text:

Andrea U J Mewes,Lilla ,Petra S ,Heidelise Als,Gloria B McAnulty,Terrie E Inder,William M Wells,Simon K Warfield,

Regional investigations of newborn MRI are important to understand the appearance and consequences of early brain injury. Previously, regionalization in neonates has been achieved with a Talairach parcellation, using internal landmarks of the brain. Non-synostotic dolichocephaly defines a bi-temporal narrowing of the preterm infant's head caused by pressure on the immature skull. The impact of dolichocephaly on brain shape and regional brain shift, which may compromise the validity of the parcellation scheme, has not yet been investigated. Twenty-four preterm and 20 fullterm infants were scanned at term equivalent. Skull shapes were investigated by cephalometric measurements and population registration. Brain tissue volumes were calculated to rule out brain injury underlying skull shape differences. The position of Talairach landmarks was evaluated. Cortical structures were segmented to determine a positional shift between both groups. The preterm group displayed dolichocephalic head shapes and had similar brain volumes compared to the mesocephalic fullterm group. In preterm infants, Talairach landmarks were consistently positioned relative to each other and to the skull base, but were displaced with regard to the calvarium. The frontal and superior region was enlarged; central and temporal gyri and sulci were shifted comparing preterm and fullterm infants. We found that, in healthy preterm infants, dolichocephaly led to a shift of cortical structures, but did not influence deep brain structures. We concluded that the validity of a Talairach parcellation scheme is compromised and may lead to a miscalculation of regional brain volumes and inconsistent parcel contents when comparing infant populations with divergent head shapes.

Displacement of brain regions in preterm infants with non-synostotic dolichocephaly investigated by MRI. Publishing Authors By Initials

AU Mewes,L ,PS ,H Als,GB McAnulty,TE Inder,WM Wells,SK Warfield,

For similar body regions: head: skull base research abstracts see: body regions: head: skull base research

PUBMED ID PMID:

MEDLINE DATE:

Displacement of brain regions in preterm infants with non-synostotic dolichocephaly investigated by MRI. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: NeuroImage

VOLUME: 36

Page Numbers: 1074-85

Journal Abbreviation: Neuroimage

ISSN: 1053-8119

DAY: 18

MONTH: 04

YEAR: 2007

Displacement of brain regions in preterm infants with non-synostotic dolichocephaly investigated by MRI. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9215515

Displacement of brain regions in preterm infants with non-synostotic dolichocephaly investigated by MRI. Keywords Mesh Terms:

KEYWORDS: Skull Base

MESH TERMS: pathology

Chemical & Substance for Abstract: Displacement of brain regions in preterm infants with non-synostotic dolichocephaly investigated by MRI. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Displacement of brain regions in preterm infants with non-synostotic dolichocephaly investigated by MRI.

AFFILIATION: Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. mewes@bwh.harvard.edu

Country: United States

AGENCY: United States NCRR

GRANT: U41RR019703-01A2

ACRONYM: RR

MEDLINETA: Neuroimage

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Displacement of brain regions in preterm infants with non-synostotic dolichocephaly investigated by MRI Related Publications

• A validation framework for brain tumor segmentation.
• Alignment of large image series using cubic B-splines tessellation: application to transmission electron microscopy data.
• An improved articulated registration method for neck images.
• Case report: explantation of a cochlear implant secondary to chronic granulating labyrinthitis.
• Compensation of geometric distortion effects on intraoperative magnetic resonance imaging for enhanced visualization in image-guided neurosurgery.
• Displacement of brain regions in preterm infants with non-synostotic dolichocephaly investigated by MRI.
• Highly accurate segmentation of brain tissue and subcortical gray matter from newborn MRI.
• Non-rigid alignment of pre-operative MRI, fMRI, and DT-MRI with intra-operative MRI for enhanced visualization and navigation in image-guided neurosurgery.
• Novel image processing techniques to better understand white matter disruption in multiple sclerosis.
• Patient-specific model of brain deformation: application to medical image registration.
• Pyloric stenosis; its problems and management; report of a case.
• Strategies and tactics for optimizing the Hit-to-Lead process and beyond-A computational chemistry perspective.
• Student usage of electronic medical record.
• The contribution of marital quality to the well-being of parents of children with developmental disabilities.
• The treatment of Rocky Mountain spotted fever.
• Three-dimensional assessment of MRI-guided percutaneous cryotherapy of liver metastases.