Dispersion of cisplatin-loaded carbon nanohorns with a conjugate comprised of an artificial peptide aptamer and polyethylene glycol.

Dispersion of cisplatin-loaded carbon nanohorns with a conjugate comprised of an artificial peptide aptamer and polyethylene glycol. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Dispersion of cisplatin-loaded carbon nanohorns with a conjugate comprised of an artificial peptide aptamer and polyethylene glycol. Abstract Text:

Sachiko Matsumura,Kumiko Ajima,Masako Yudasaka,Sumio Iijima,Kiyotaka Shiba,Sachiko Matsumura,Kumiko Ajima,Masako Yudasaka,Sumio Iijima,Kiyotaka Shiba,

Hydrophobic single-wall carbon nanohorns (SWNHs) were dispersed in aqueous media by noncovalently modifying their surfaces with conjugate molecules comprised of polyethylene glycol (PEG) and a peptide aptamer (NHBP-1) that specifically bind to the surfaces of the SWNHs. The conjugates were synthesized by coupling PEG (average molecular weights of 20,000 and 5000) to the N-terminus of NHBP-1 to produce 20PEG-NHBP and 5PEG-NHBP, respectively. Oxidized SWNHs (oxSWNHs) mixed with 20PEG-NHBP or 5PEG-NHBP were well dispersed in water and passed through a gel filtration column, whereas the oxSWNHs treated with PEG stuck to the top of the column. Although the presence of salts in the media significantly impaired the dispersibility of the oxSWNHs, the oxSWNHs/20PEG-NHBP complexes were well dispersed in both the phosphate-buffered saline (PBS) and cell culture medium. The amount of 20PEG-NHBP bound to the oxSWNHs was estimated to be 0.32 g/g of oxSWNHs, and a dynamic light scattering analysis revealed the diameter of the oxSWNHs/20PEG-NHBP complex to be approximately 210 nm. We then showed that CDDP@oxSWNHs/20PEG-NHBP, in which the cancer chemotherapy drug cisplatin (CDDP) was loaded inside the oxSWNHs, was well dispersed in both the PBS and culture medium and exerted a potent cytotoxic effect against cancer cells. The good dispersion of drug-loaded carbon nanomaterials, like that seen here, is a prerequisite for the clinical application of such materials.

Dispersion of cisplatin-loaded carbon nanohorns with a conjugate comprised of an artificial peptide aptamer and polyethylene glycol. Publishing Authors By Initials

S Matsumura,K Ajima,M Yudasaka,S Iijima,K Shiba,S Matsumura,K Ajima,M Yudasaka,S Iijima,K Shiba,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Dispersion of cisplatin-loaded carbon nanohorns with a conjugate comprised of an artificial peptide aptamer and polyethylene glycol. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular pharmaceutics

VOLUME: 4

Page Numbers: 723-9

Journal Abbreviation: Mol. Pharm.

ISSN: 1543-8384

DAY: 9

MONTH: 08

YEAR: 2007

Dispersion of cisplatin-loaded carbon nanohorns with a conjugate comprised of an artificial peptide aptamer and polyethylene glycol. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101197791

Dispersion of cisplatin-loaded carbon nanohorns with a conjugate comprised of an artificial peptide aptamer and polyethylene glycol. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Dispersion of cisplatin-loaded carbon nanohorns with a conjugate comprised of an artificial peptide aptamer and polyethylene glycol. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Dispersion of cisplatin-loaded carbon nanohorns with a conjugate comprised of an artificial peptide aptamer and polyethylene glycol.

AFFILIATION: SORST-JST, c/o NEC Corporation, 34 Miyukigaoka, Tsukuba, Ibaraki 305-8501, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Mol Pharm

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Dispersion of cisplatin-loaded carbon nanohorns with a conjugate comprised of an artificial peptide aptamer and polyethylene glycol Related Publications

• A hexapeptide motif that electrostatically binds to the surface of titanium.
• A simple staining method for dna and rna blotted on a membrane using a polyethyleneimine-enzyme conjugate.
• Activation of the FGF signaling pathway and subsequent induction of mesenchymal stem cell differentiation by inorganic polyphosphate.
• Analysis of volatile compounds in beef fat by dynamic-headspace solid-phase microextraction combined with gas chromatography-mass spectrometry.
• Dispersion of cisplatin-loaded carbon nanohorns with a conjugate comprised of an artificial peptide aptamer and polyethylene glycol.
• Echo sounder transducer.
• Endowing a ferritin-like cage protein with high affinity and selectivity for certain inorganic materials.
• Immunohistochemical observation of actin filaments in epithelial cells encircling the taste pore cavity of rat fungiform papillae.
• In aqua structuralization of a three-dimensional configuration using biomolecules.
• Involvement of cytoskeletal integrity in the regulation of Cl(-) and amylase secretion from rat parotid acinar cells.
• Locomotion assistance for the person with mobility impairment: fuzzy control of cycling movement by means of surface electrical-stimulation.
• Motif-programmed artificial protein induces apoptosis in several cancer cells by disrupting mitochondria.
• Suppression of carbachol-induced oscillatory Cl- secretion by forskolin in rat parotid and submandibular acinar cells.
• Synthesis of functional proteins by mixing peptide motifs.
• The role of peptide motifs in the evolution of a protein network.
• Underwater vehicle attitude estimation using Hough transformation.
• [A case of surgical treatment of triple cancer]
• [The effect of air massage on serum constituents]