Disorders of steroid 11beta-hydroxylase isozymes.

Disorders of steroid 11beta-hydroxylase isozymes. Research Abstract Details 

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Disorders of steroid 11beta-hydroxylase isozymes. Abstract Text:

Steroid 11 beta-hydroxylase activity in the adrenal cortex is required for the synthesis of the major glucocorticoids and mineralocorticoids, but different isozymes mediate this conversion in the zona fasciculata, where cortisol is produced, and the zona glomerulosa, the site of aldosterone synthesis. The isozyme in the latter zone also has 18-hydroxylase and 18-oxidase activities that are required for aldosterone synthesis. Mutations in the genes encoding these isozymes respectively result in defective synthesis of cortisol and aldosterone. Recombinations between the two genes that alter the regulation of the isozyme responsible for aldosterone synthesis cause an inherited form of hypertension, glucocorticoid-suppressible hyperaldosteronism.

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Disorders of steroid 11beta-hydroxylase isozymes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Trends in endocrinology and metabolism: TEM

VOLUME: 3

Page Numbers: 229-34

Journal Abbreviation: Trends Endocrinol. Metab.

ISSN: 1043-2760

DAY: 14

MONTH: Aug

YEAR: 1992

Disorders of steroid 11beta-hydroxylase isozymes. Information

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LANGUAGE: eng

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AFFILIATION: Division of Pediatric Endocrinology, Cornell University Medical College, New York, NY 10021, USA.

Country: United States

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MEDLINETA: Trends Endocrinol Metab

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