Disorders of platelet function: mechanisms, diagnosis and management.

Disorders of platelet function: mechanisms, diagnosis and management. Research Abstract Details 

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Disorders of platelet function: mechanisms, diagnosis and management. Abstract Text:

Platelets play an important role in hemostasis, and alterations in platelet function may be the cause of abnormal bleeding in a wide variety of congenital and acquired clinical disorders. Platelet dysfunction may be classified as disorders of (1) substrate connective tissue, (2) adhesion, (3) aggregation and (4) platelet-release reaction. The congenital defects of platelet function, although uncommon, have provided important insights into platelet physiology and pathophysiology and, as a group, are less common, better characterized and more readily classified than the acquired defects.The severity of bleeding resulting from platelet dysfunction varies greatly and is substantially increased when another defect of hemostasis coexists. A disorder of platelet function is suspected on the basis of the history and physical examination and is confirmed by the finding of a prolonged bleeding time in the presence of an adequate number of platelets. A specific diagnosis often requires measurements of the factor VIII and von Willebrand factor complex and other tests of platelet function. Some of these tests may be available only in specialized laboratories.Therapy for bleeding episodes resulting from platelet dysfunction is directed at (1) removing or treating the underlying cause of the platelet disorder; (2) replacing the missing plasma cofactors needed to support normal platelet function (such as by the transfusion of cryoprecipitate in patients with von Willebrand disease, and (3) transfusing functional platelets in the form of platelet concentrates in patients with disorders of intrinsic platelet dysfunction.

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MEDLINE DATE:

Disorders of platelet function: mechanisms, diagnosis and management. Journal Published:

PUBLICATION TYPE: Review

Journal: The Western journal of medicine

VOLUME: 134

Page Numbers: 109-27

Journal Abbreviation: West. J. Med.

ISSN: 0093-0415

DAY: 4

MONTH: Feb

YEAR: 1981

Disorders of platelet function: mechanisms, diagnosis and management. Information

Number of References: 121

LANGUAGE: eng

NlmUniqueID: 410504

Disorders of platelet function: mechanisms, diagnosis and management. Keywords Mesh Terms:

KEYWORDS: von Willebrand Disease

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Disorders of platelet function: mechanisms, diagnosis and management. Information

Substance Name: Anti-Inflammatory Agents

Registry Number: 0

Grant and Affiliation Information for Disorders of platelet function: mechanisms, diagnosis and management.

AFFILIATION:

Country: UNITED STATES

AGENCY: United States NHLBI

GRANT: HL-LL775

ACRONYM: HL

MEDLINETA: West J Med

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