Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X(7) Receptor Antagonists/Interleukin-1beta Inhibitors.

Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X(7) Receptor Antagonists/Interleukin-1beta Inhibitors. Research Abstract Details 

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Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X(7) Receptor Antagonists/Interleukin-1beta Inhibitors. Abstract Text:

Mark Furber,Lilian Alcaraz,Janice E Bent,Armin Beyerbach,Keith Bowers,Martin Braddock,Moya V Caffrey,David Cladingboel,John Collington,David K Donald,Malbinder Fagura,Frank Ince,Elizabeth C Kinchin,Celine Laurent,Mandy Lawson,Timothy J Luker,Michael M P Mortimore,Austen D Pimm,Robert J Riley,Nicola Roberts,Mark Robertson,Jill Theaker,Philip V Thorne,Richard Weaver,Peter Webborn,Paul Willis,Mark Furber,Lilian Alcaraz,Janice E Bent,Armin Beyerbach,Keith Bowers,Martin Braddock,Moya V Caffrey,David Cladingboel,John Collington,David K Donald,Malbinder Fagura,Frank Ince,Elizabeth C Kinchin,Celine Laurent,Mandy Lawson,Timothy J Luker,Michael M P Mortimore,Austen D Pimm,Robert J Riley,Nicola Roberts,Mark Robertson,Jill Theaker,Philip V Thorne,Richard Weaver,Peter Webborn,Paul Willis,

A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat P2X7 receptor and provides useful pharmacological tools for evaluation of the role of P2X7 in disease.

Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X(7) Receptor Antagonists/Interleukin-1beta Inhibitors. Publishing Authors By Initials

M Furber,L Alcaraz,JE Bent,A Beyerbach,K Bowers,M Braddock,MV Caffrey,D Cladingboel,J Collington,DK Donald,M Fagura,F Ince,EC Kinchin,C Laurent,M Lawson,TJ Luker,MM Mortimore,AD Pimm,RJ Riley,N Roberts,M Robertson,J Theaker,PV Thorne,R Weaver,P Webborn,P Willis,M Furber,L Alcaraz,JE Bent,A Beyerbach,K Bowers,M Braddock,MV Caffrey,D Cladingboel,J Collington,DK Donald,M Fagura,F Ince,EC Kinchin,C Laurent,M Lawson,TJ Luker,MM Mortimore,AD Pimm,RJ Riley,N Roberts,M Robertson,J Theaker,PV Thorne,R Weaver,P Webborn,P Willis,

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Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X(7) Receptor Antagonists/Interleukin-1beta Inhibitors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of medicinal chemistry

VOLUME: 50

Page Numbers: 5882-5

Journal Abbreviation: J. Med. Chem.

ISSN: 0022-2623

DAY: 27

MONTH: 10

YEAR: 2007

Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X(7) Receptor Antagonists/Interleukin-1beta Inhibitors. Information

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LANGUAGE: eng

NlmUniqueID: 9716531

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AFFILIATION: Departments of Medicinal Chemistry, Discovery Bioscience, and Physical and Metabolic Science, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leics LE11 5RH, U.K.

Country: United States

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MEDLINETA: J Med Chem

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