Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr.

Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr. Research Abstract Details 

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Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr. Abstract Text:

Celia Dominguez,Leon Smith,Qi Huang,Chester Yuan,Xiaohu Ouyang,Lynn Cai,Paul Chen,Joseph Kim,Timothy Harvey,Rashid Syed,Tae-Seong Kim,Andrew Tasker,Ling Wang,Michael Zhang,Angela Coxon,James Bready,Charles Starnes,Danlin Chen,Yongmei Gan,Sesha Neervannan,Gondi Kumar,Anthony Polverino,Richard Kendall,Celia Dominguez,Leon Smith,Qi Huang,Chester Yuan,Xiaohu Ouyang,Lynn Cai,Paul Chen,Joseph Kim,Timothy Harvey,Rashid Syed,Tae-Seong Kim,Andrew Tasker,Ling Wang,Michael Zhang,Angela Coxon,James Bready,Charles Starnes,Danlin Chen,Yongmei Gan,Sesha Neervannan,Gondi Kumar,Anthony Polverino,Richard Kendall,

Inhibition of tumor-induced angiogenesis is a promising strategy in anticancer research. Neovascularization is a process required for both tumor growth and metastasis. Enhanced understanding of the underlying molecular mechanisms has led to the discovery of a variety of pharmaceutically attractive targets. Decades of investigation suggest that vascular endothelial growth factor (VEGF) and its receptors, in particular VEGFR2 or kinase insert-domain-containing receptor (Kdr), play a critical role in the growth and survival of endothelial cells in newly forming vasculature. The clinical utility of inhibitors of this receptor tyrosine kinase is currently under intense investigation. Herein we report our efforts in this arena.

Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr. Publishing Authors By Initials

C Dominguez,L Smith,Q Huang,C Yuan,X Ouyang,L Cai,P Chen,J Kim,T Harvey,R Syed,TS Kim,A Tasker,L Wang,M Zhang,A Coxon,J Bready,C Starnes,D Chen,Y Gan,S Neervannan,G Kumar,A Polverino,R Kendall,C Dominguez,L Smith,Q Huang,C Yuan,X Ouyang,L Cai,P Chen,J Kim,T Harvey,R Syed,TS Kim,A Tasker,L Wang,M Zhang,A Coxon,J Bready,C Starnes,D Chen,Y Gan,S Neervannan,G Kumar,A Polverino,R Kendall,

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Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 6003-8

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 22

MONTH: 08

YEAR: 2007

Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

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AFFILIATION: Chemistry Research and Discovery, One Amgen Center Drive Thousand Oaks, CA 91320, USA. celia.dominguez@chdi-inc.org

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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