Discovery and SAR studies of novel GlyT1 inhibitors.

Discovery and SAR studies of novel GlyT1 inhibitors. Research Abstract Details 

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Discovery and SAR studies of novel GlyT1 inhibitors. Abstract Text:

Magnus W Walter,Beth J Hoffman,Kimberly Gordon,Kirk Johnson,Patrick Love,Matthew Jones,Teresa Man,Lee Phebus,Jon K Reel,Helene C Rudyk,Harlan Shannon,Kjell Svensson,Hong Yu,Matthew J Valli,Warren J Porter,Magnus W Walter,Beth J Hoffman,Kimberly Gordon,Kirk Johnson,Patrick Love,Matthew Jones,Teresa Man,Lee Phebus,Jon K Reel,Helene C Rudyk,Harlan Shannon,Kjell Svensson,Hong Yu,Matthew J Valli,Warren J Porter,

Inhibition of the glycine transporter GlyT1 is a potential strategy for the treatment of schizophrenia. A novel series of GlyT1 inhibitors and their structure-activity relationships (SAR) are described. Members of this series are highly potent and selective transport inhibitors which are shown to elevate glycine levels in cerebrospinal fluid.

Discovery and SAR studies of novel GlyT1 inhibitors. Publishing Authors By Initials

MW Walter,BJ Hoffman,K Gordon,K Johnson,P Love,M Jones,T Man,L Phebus,JK Reel,HC Rudyk,H Shannon,K Svensson,H Yu,MJ Valli,WJ Porter,MW Walter,BJ Hoffman,K Gordon,K Johnson,P Love,M Jones,T Man,L Phebus,JK Reel,HC Rudyk,H Shannon,K Svensson,H Yu,MJ Valli,WJ Porter,

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Discovery and SAR studies of novel GlyT1 inhibitors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 5233-8

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 30

MONTH: 06

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9107377

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Grant and Affiliation Information for Discovery and SAR studies of novel GlyT1 inhibitors.

AFFILIATION: Lilly Research Laboratories, Eli Lilly and Company, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK. magnus.walter@lilly.com

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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