Discordant beta-blocker effects on clinic, ambulatory, resting, and exercise hemodynamics in patients with hypertension.

Discordant beta-blocker effects on clinic, ambulatory, resting, and exercise hemodynamics in patients with hypertension. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Discordant beta-blocker effects on clinic, ambulatory, resting, and exercise hemodynamics in patients with hypertension. Abstract Text:

Amber L Beitelshees,Issam Zineh,Hossein N Yarandi,Daniel F Pauly,Julie A Johnson,

STUDY OBJECTIVES: To determine the correlation between ambulatory and clinic blood pressure in assessing antihypertensive response to beta-blockade, to test whether blood pressure response to metoprolol is associated with the heart rate response, and to determine whether exercise and resting heart rate responses to metoprolol are correlated. DESIGN: Post hoc analysis of a prospective cohort study. SETTING: University-affiliated general clinical research center. PATIENTS: Fifty-one patients aged 35-65 years with uncomplicated hypertension. Intervention. All patients received metoprolol at a dosage titrated to achieve a diastolic blood pressure below 90 mm Hg. MEASUREMENTS AND MAIN RESULTS: Clinic and 24-hour ambulatory blood pressure measurements were obtained and exercise treadmill testing was performed before and after metoprolol treatment. Based on ambulatory blood pressure data, 24 patients (47%) responded (defined as at least a 10% reduction in diastolic blood pressure) to metoprolol compared with 36 patients (71%) based on clinic blood pressure data (p=0.027). Clinic blood pressure was associated with a 67% false-positive rate (responsive blood pressure by clinic data that was actually nonresponsive by ambulatory data). Blood pressure responders and nonresponders exhibited similar reductions in exercise heart rate (24% and 23%, p=0.74). However, responses to metoprolol measured by exercise heart rate versus resting heart rate were not significantly correlated (r=0.24, p=0.105). CONCLUSION: Reliance on clinic blood pressure or resting heart rate for making beta-blocker treatment decisions may yield less than optimal assessment of the antihypertensive response or degree of beta-blockade.

Discordant beta-blocker effects on clinic, ambulatory, resting, and exercise hemodynamics in patients with hypertension. Publishing Authors By Initials

AL Beitelshees,I Zineh,HN Yarandi,DF Pauly,JA Johnson,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Discordant beta-blocker effects on clinic, ambulatory, resting, and exercise hemodynamics in patients with hypertension. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pharmacotherapy

VOLUME: 26

Page Numbers: 1247-54

Journal Abbreviation:

ISSN: 0277-0008

DAY: 3

MONTH: Sep

YEAR: 2006

Discordant beta-blocker effects on clinic, ambulatory, resting, and exercise hemodynamics in patients with hypertension. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8111305

Discordant beta-blocker effects on clinic, ambulatory, resting, and exercise hemodynamics in patients with hypertension. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Discordant beta-blocker effects on clinic, ambulatory, resting, and exercise hemodynamics in patients with hypertension. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Discordant beta-blocker effects on clinic, ambulatory, resting, and exercise hemodynamics in patients with hypertension.

AFFILIATION: Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville, Florida 32610-0486, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Pharmacotherapy

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Discordant beta-blocker effects on clinic, ambulatory, resting, and exercise hemodynamics in patients with hypertension Related Publications

• A Phase I Trial of Outpatient Weekly Docetaxel and Concurrent Radiation Therapy for Stage III Unresectable Non Small-Cell Lung Cancer: A Vanderbilt Cancer Center Affiliate Network (VCCAN) Trial.
• A method for one-step freezing of mouse embryos.
• Active immunization of boars against gonadotrop in releasing hormone. I. Effects on reproductive parameters.
• Active immunization of boars against gonadotropin releasing hormone. II. Effects on libido and response to testosterone propionate.
• An eight-position capillary sample spinning stage for the diffractometer at BL20B at the Photon Factory.
• An extract of the mushroom Agaricus blazei Murill protects against lethal septicemia in a mouse model of fecal peritonitis.
• Cardiac hypertrophy in infancy.
• Effect of castration on plasma luteinizing hormone in postpubertal boars.
• Effects of postparturient uterine lavage on uterine involution in the mare.
• Effects of pretreatment with adrenocorticotropin on endocrine and behavioral responses of bulls to sexual activity.
• Effects of zeranol upon bovine testicular function.
• Embryo transfer tests for bovine syndactyly.
• Evaluation of recombinant human bone morphogenetic protein-2 as a bone-graft substitute in a canine segmental defect model.
• Factors related to successful sperm microinjection of hamster eggs: The effect of sperm species, technical experience, needle dimensions, and incubation medium on egg viability and sperm decondensation following microinjection.
• Leading from the edge, and toward the light: some lessons on leadership from the business world.
• Progesterone profiles in postpartum Holstein dairy cows as an aid in the study of retained fetal membranes, pyometra and anestrus.
• Quantum-dot-based nanosensor for RRE IIB RNA-Rev peptide interaction assay.
• Relationship between serum luteinizing hormone and estradiol in prepubertal boars.
• Scrotal circumference does not accurately predict degree of germinal epithelial loss or semen quality in yearling Hereford and Simmental bulls.
• Single site electronic spectroscopy of free base octaethylporphyrin, octaethychlorin and their diacids in n-octane at 298K and 7K.
• Single site electronic spectroscopy of magnesium isobacteriochlorin in n-octane matrixes at 7 K.
• Skin and subcutaneous tissue in rhinoplasty.
• Techniques of Online Citation Verification in NLM Databases.
• Temporal relationships among peripheral blood concentrations of corticosteroids, luteinizing hormone and testosterone in bulls.
• Testing the adaptive value of circadian systems.
• The effect of co-treatment with recombinant bovine somatotrophin on plasma progesterone concentration and number of embryos collected from superovulated Holstein heifers.
• The effect of prostaglandin administration to Holstein-Friesian cows at Day 26 postpartum on clinical findings, and histological and bacteriological results of endometrial biopsies at Day 40.
• The recovery of ureaplasmas from bovine embryos following in vitro exposure and ten washes.
• The use of real-time ultrasound rectally for early pregnancy diagnosis in sheep.
• Variation in testosterone production among boards and its relationship to sexual interest and breeding performance.