Directly measured insulin resistance and the assessment of clustered cardiovascular risks in hypertension.

Directly measured insulin resistance and the assessment of clustered cardiovascular risks in hypertension. Research Abstract Details 

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Directly measured insulin resistance and the assessment of clustered cardiovascular risks in hypertension. Abstract Text:

Ming-Wei Lin,Chii-Min Hwu,Yung-Hsiang Huang,Wayne H-H Sheu,Kuang-Chung Shih,Fu-Tien Chiang,Richard Olshen,Yii-Der I Chen,J David Curb,Beatriz Rodriguez,Low-Tone Ho, ,

BACKGROUND: The purpose of the study was to use factor analysis to investigate the contribution of a directly measured insulin sensitivity index, steady-state plasma glucose (SSPG) from insulin suppression test (IST), to a clustering of cardiovascular risk factors in hypertensive subjects. METHODS: A total of 204 nondiabetic hypertensive patients who received IST for SSPG were included for current analysis. Factor analysis was performed to explore the contribution of SSPG as additional information to a clustering of risk factors in these subjects. RESULTS: In factor analysis, SSPG aggregated with metabolic variables in an obesity-hyperinsulinemia domain that included two factors: one with positive loadings for SSPG, 2-h glucose, and Log 2-h insulin; and the other with positive loadings for body mass index, waist circumference, and fasting glucose. Fasting insulin linked the two factors together and explained 38.3% of the total variance. Systolic and diastolic blood pressures were loaded on a blood pressure domain separately. The third domain consisted of two factors: one with positive loadings for Log triglycerides and negative loading for high-density lipoprotein cholesterol; and the other with positive loadings for Log triglycerides and non-high-density lipoprotein cholesterol. The model loaded without SSPG explained a proportion of the total variance (78.5%) similar to that achieved with the model loaded with SSPG (77.1%). CONCLUSIONS: Directly measured insulin sensitivity index SSPG clustered with 2-h glucose and Log 2-h insulin in factor analysis in a cohort consisting entirely of hypertensive subjects. However, the contribution of SSPG as additional information to explain the total variance seems to be insignificant.

Directly measured insulin resistance and the assessment of clustered cardiovascular risks in hypertension. Publishing Authors By Initials

MW Lin,CM Hwu,YH Huang,WH Sheu,KC Shih,FT Chiang,R Olshen,YD Chen,JD Curb,B Rodriguez,LT Ho, ,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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Directly measured insulin resistance and the assessment of clustered cardiovascular risks in hypertension. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of hypertension : journal of the

VOLUME: 19

Page Numbers: 1118-24

Journal Abbreviation: Am. J. Hypertens.

ISSN: 0895-7061

DAY: 3

MONTH: Nov

YEAR: 2006

Directly measured insulin resistance and the assessment of clustered cardiovascular risks in hypertension. Information

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LANGUAGE: eng

NlmUniqueID: 8803676

Directly measured insulin resistance and the assessment of clustered cardiovascular risks in hypertension. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Directly measured insulin resistance and the assessment of clustered cardiovascular risks in hypertension. Information

Substance Name: Blood Glucose

Registry Number: 0

Grant and Affiliation Information for Directly measured insulin resistance and the assessment of clustered cardiovascular risks in hypertension.

AFFILIATION: Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.

Country: United States

AGENCY: United States NHLBI

GRANT: U01HL54527-0151

ACRONYM: HL

MEDLINETA: Am J Hypertens

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