Directional memory and caged dynamics in cytoskeletal remodelling.

Directional memory and caged dynamics in cytoskeletal remodelling. Research Abstract Details 

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Directional memory and caged dynamics in cytoskeletal remodelling. Abstract Text:

Guillaume Lenormand,Julien Chopin,Predrag Bursac,Jeffrey J Fredberg,James P Butler,

We report directional memory of spontaneous nanoscale displacements of an individual bead firmly anchored to the cytoskeleton of a living cell. A novel method of analysis shows that for shorter time intervals cytoskeletal displacements are antipersistent and thus provides direct evidence in a living cell of molecular trapping and caged dynamics. At longer time intervals displacements are persistent. The transition from antipersistence to persistence is indicative of a time-scale for cage rearrangements and is found to depend upon energy release due to ATP hydrolysis and proximity to a glass transition. Anomalous diffusion is known to imply memory, but we show here that memory is attributed to direction rather than step size. As such, these data are the first to provide a molecular-scale physical picture describing the cytoskeletal remodelling process and its rate of progression.

Directional memory and caged dynamics in cytoskeletal remodelling. Publishing Authors By Initials

G Lenormand,J Chopin,P Bursac,JJ Fredberg,JP Butler,

For similar respiratory system: trachea research abstracts see: respiratory system: trachea research

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Directional memory and caged dynamics in cytoskeletal remodelling. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biochemical and biophysical research communication

VOLUME: 360

Page Numbers: 797-801

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 5

MONTH: 07

YEAR: 2007

Directional memory and caged dynamics in cytoskeletal remodelling. Information

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LANGUAGE: eng

NlmUniqueID: 372516

Directional memory and caged dynamics in cytoskeletal remodelling. Keywords Mesh Terms:

KEYWORDS: Trachea

MESH TERMS: metabolism

Chemical & Substance for Abstract: Directional memory and caged dynamics in cytoskeletal remodelling. Information

Substance Name: Adenosine Triphosphate

Registry Number: 56-65-5

Grant and Affiliation Information for Directional memory and caged dynamics in cytoskeletal remodelling.

AFFILIATION: Molecular and Integrative Physiological Sciences, Department of Environmental Health, School of Public Health, Harvard University, Boston, MA 02115, USA. glenorma@hsph.harvard.edu

Country: United States

AGENCY: United States NIAID

GRANT: HL/AI 65960

ACRONYM: AI

MEDLINETA: Biochem Biophys Res Commun

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