Direct NMR analysis of cannabis water extracts and tinctures and semi-quantitative data on Delta(9)-THC and Delta(9)-THC-acid.

Direct NMR analysis of cannabis water extracts and tinctures and semi-quantitative data on Delta(9)-THC and Delta(9)-THC-acid. Research Abstract Details 

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Direct NMR analysis of cannabis water extracts and tinctures and semi-quantitative data on Delta(9)-THC and Delta(9)-THC-acid. Abstract Text:

M Politi,W Peschel,N Wilson,M Zloh,J M Prieto,M Heinrich,

Cannabis sativa L. is the source for a whole series of chemically diverse bioactive compounds that are currently under intensive pharmaceutical investigation. In this work, hot and cold water extracts as well as ethanol/water mixtures (tinctures) of cannabis were compared in order to better understand how these extracts differ in their overall composition. NMR analysis and in vitro cell assays of crude extracts and fractions were performed. Manufacturing procedures to produce natural remedies can strongly affect the final composition of the herbal medicines. Temperature and polarity of the solvents used for the extraction resulted to be two factors that affect the total amount of Delta(9)-THC in the extracts and its relative quantity with respect to Delta(9)-THC-acid and other metabolites. Diffusion-edited (1)H NMR (1D DOSY) and (1)H NMR with suppression of the ethanol and water signals were used. With this method it was possible, without any evaporation or separation step, to distinguish between tinctures from different cannabis cultivars. This approach is proposed as a direct analysis of plant tinctures.

Direct NMR analysis of cannabis water extracts and tinctures and semi-quantitative data on Delta(9)-THC and Delta(9)-THC-acid. Publishing Authors By Initials

M Politi,W Peschel,N Wilson,M Zloh,JM Prieto,M Heinrich,

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Direct NMR analysis of cannabis water extracts and tinctures and semi-quantitative data on Delta(9)-THC and Delta(9)-THC-acid. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Phytochemistry

VOLUME: 69

Page Numbers: 562-70

Journal Abbreviation: Phytochemistry

ISSN: 0031-9422

DAY: 26

MONTH: 10

YEAR: 2007

Direct NMR analysis of cannabis water extracts and tinctures and semi-quantitative data on Delta(9)-THC and Delta(9)-THC-acid. Information

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LANGUAGE: eng

NlmUniqueID: 151434

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Grant and Affiliation Information for Direct NMR analysis of cannabis water extracts and tinctures and semi-quantitative data on Delta(9)-THC and Delta(9)-THC-acid.

AFFILIATION: Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

Country: United States

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MEDLINETA: Phytochemistry

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