Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains.

Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains. Research Abstract Details 

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Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains. Abstract Text:

Michal Pravenec,Masaya Hyakukoku,Josef Houstek,Vaclav Zidek,Vladimir Landa,Petr Mlejnek,Ivan Miksik,Kristyna ,Petr Pecina,Marek Vrbacky,Zdenek Drahota,Alena Vojtiskova,Tomas Mracek,Ludmila Kazdova,Olena Oliyarnyk,Jiaming Wang,Christopher Ho,Nathan Qi,Ken Sugimoto,Theodore Kurtz,

Recently, the relationship of mitochondrial DNA (mtDNA) variants to metabolic risk factors for diabetes and other common diseases has begun to attract increasing attention. However, progress in this area has been limited because (1) the phenotypic effects of variation in the mitochondrial genome are difficult to isolate owing to confounding variation in the nuclear genome, imprinting phenomena, and environmental factors; and (2) few animal models have been available for directly investigating the effects of mtDNA variants on complex metabolic phenotypes in vivo. Substitution of different mitochondrial genomes on the same nuclear genetic background in conplastic strains provides a way to unambiguously isolate effects of the mitochondrial genome on complex traits. Here we show that conplastic strains of rats with identical nuclear genomes but divergent mitochondrial genomes that encode amino acid differences in proteins of oxidative phosphorylation exhibit differences in major metabolic risk factors for type 2 diabetes. These results (1) provide the first direct evidence linking naturally occurring variation in the mitochondrial genome, independent of variation in the nuclear genome and other confounding factors, to inherited variation in known risk factors for type 2 diabetes; and (2) establish that spontaneous variation in the mitochondrial genome per se can promote systemic metabolic disturbances relevant to the pathogenesis of common diseases.

Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains. Publishing Authors By Initials

M Pravenec,M Hyakukoku,J Houstek,V Zidek,V Landa,P Mlejnek,I Miksik,K ,P Pecina,M Vrbacky,Z Drahota,A Vojtiskova,T Mracek,L Kazdova,O Oliyarnyk,J Wang,C Ho,N Qi,K Sugimoto,T Kurtz,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genome research

VOLUME: 17

Page Numbers: 1319-26

Journal Abbreviation: Genome Res.

ISSN: 1088-9051

DAY: 10

MONTH: 08

YEAR: 2007

Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9518021

Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains. Information

Substance Name: Electron Transport Complex IV

Registry Number: EC 1.9.3.1

Grant and Affiliation Information for Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains.

AFFILIATION: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic.

Country: United States

AGENCY: United States NHLBI

GRANT: HL63709

ACRONYM: HL

MEDLINETA: Genome Res

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