Direct infection of colony forming unit-megakaryocyte by human cytomegalovirus contributes the pathogenesis of idiopathic thrombocytopenic purpura.

Direct infection of colony forming unit-megakaryocyte by human cytomegalovirus contributes the pathogenesis of idiopathic thrombocytopenic purpura. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Direct infection of colony forming unit-megakaryocyte by human cytomegalovirus contributes the pathogenesis of idiopathic thrombocytopenic purpura. Abstract Text:

Yan Xiao,Wen Lin,Qin Liu,Runming Jin,Hongbao Fei,

Human cytomegalovirus (HCMV) late mRNA expression in megakaryoblast and in turn the pathogenesis of idiopathic thrombocytopenic purpura (ITP) patients with HCMV infection, and effectiveness of ganciclovir were investigated. Colony forming unit-megakaryocytes (CFU-MK) of 46 ITP patients with HCMV infection were incubated from patients' bone marrow mononuclear cells (MNC). Reverse transcriptase-polymerase chain reaction (RT-PCR) was subsequently used for CFU-MK for HCMV-late mRNA detection. Ganciclovir therapy was given to both HCMV-late mRNA positive and negative groups for comparison of therapeutic effectiveness. The results in 19 of 46 CFU-MK culture cells specimens with positive HCMV-DNA by PCR or positive CMV-IgM by enzyme linked immunosorbent assay (ELISA) in the correspondent serum of peripheral blood were positive for HCMV-late mRNA. Sixteen out of 19, patients with positive HCMV-late mRNA CFU-MK had a positive response to ganciclovir. Amongst 27 patients with negative HCMV-late mRNA CFU-MK, only 4 positive responders to ganciclovir therapy were observed. Curative effectiveness of ganciclovir in HCMV-late mRNA positive group was significantly higher than that in HCMV-late mRNA negative group (P<0.01). It was suggested that HCMV could directly infect CFU-MK, which might be one of the mechanisms responsible for HCMV related ITP. The ganciclovir is an effective therapy in resulting in the increases in thrombocyte in the ITP patients whose HCMV- late mRNA was positive in their CFU-MK.

Direct infection of colony forming unit-megakaryocyte by human cytomegalovirus contributes the pathogenesis of idiopathic thrombocytopenic purpura. Publishing Authors By Initials

Y Xiao,W Lin,Q Liu,R Jin,H Fei,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Direct infection of colony forming unit-megakaryocyte by human cytomegalovirus contributes the pathogenesis of idiopathic thrombocytopenic purpura. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of Huazhong University of Science and Tech

VOLUME: 26

Page Numbers: 555-7

Journal Abbreviation: J. Huazhong Univ. Sci. Technol

ISSN: 1672-0733

DAY: 15

MONTH: 01

YEAR: 2006

Direct infection of colony forming unit-megakaryocyte by human cytomegalovirus contributes the pathogenesis of idiopathic thrombocytopenic purpura. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101169627

Direct infection of colony forming unit-megakaryocyte by human cytomegalovirus contributes the pathogenesis of idiopathic thrombocytopenic purpura. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Direct infection of colony forming unit-megakaryocyte by human cytomegalovirus contributes the pathogenesis of idiopathic thrombocytopenic purpura. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Direct infection of colony forming unit-megakaryocyte by human cytomegalovirus contributes the pathogenesis of idiopathic thrombocytopenic purpura.

AFFILIATION: Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Huazhong Univ Sci Technolog

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Direct infection of colony forming unit-megakaryocyte by human cytomegalovirus contributes the pathogenesis of idiopathic thrombocytopenic purpura Related Publications

• Automatic 3D-to-2D registration for CT and dual-energy digital radiography for calcification detection.
• Cloning of full length cDNA sequence of the mouse ameloblastin.
• Development of a heat shock inducible and inheritable RNAi system in silkworm.
• Direct infection of colony forming unit-megakaryocyte by human cytomegalovirus contributes the pathogenesis of idiopathic thrombocytopenic purpura.
• FANCD2 monoubiquitination provides a link between the HHR6 and FA-BRCA pathways.
• Feasibility of bone marrow stromal cells autologous transplantation for dilated cardiomyopathy.
• High aerobic capacity does not attenuate aortic stiffness in hypertensive subjects.
• Hypoalgesia in mice lacking GABA transporter subtype 1.
• Improved method to raise polyclonal antibody using enhanced green fluorescent protein transgenic mice.
• MR Imaging of nonalcoholic Wernicke encephalopathy: a follow-up study.
• Seizures associated with ertapenem.
• Studying on the 19-bp palindrome repeats in human cytomegalovirus immediate early enhancer/promoter reveals their diversity in function for the promoter activity.
• The Protecting Effects and Mechanisms of Baicalin and Octreotide on Heart Injury in Rats with SAP.
• Yin yang 1 directly regulates the transcription of RE-1 silencing transcription factor.
• [A clinical study on human cytomegalovirus infection in colony forming unit-megakaryocyte in patients with idiopathic thrombocytopenic purpura]
• [Anti-tumor activity and immune responses induced by human cancer-associated mucin core peptide]
• [Application of qualitative research method in clinical study on acupuncture and moxibustion]
• [Biological response of B-cell lymphoma cells in vitro to 131I-rituximab]
• [Construction of an angiostatin eukaryotic expression vector and characterization of its inhibitory efficiency in B16 melanoma bearing mice]
• [Effect of fibrinogen on the adherence of Porphyromonas gingivalis to human oral epithelial cells]
• [Effect of insulin-like growth factor I on the transdifferentiation and collagen synthesis of human renal tubular epithelial cells]
• [Effective expression of ribonuclease-onconase in Escherichia coli and assaying its cytotoxic potential]
• [Effects of Nurr1 down-regulation on the expression of tyrosine hydroxylase and neurite extension in dopaminergic cells.]
• [Establishment of mouse melanoma model expressing beta-galactosidase and its application in the research of DNA vaccines against tumor]
• [Ethanol affects the function of gamma-aminobutyric acid transporter I in mice brain]
• [Generation of transgenic mouse of dentin sialoprotein and transgene expression analysis]
• [Inclusion constant of beta-CD and paeonol measured by phase solubility method]
• [MAPK signal pathway plays a role in proliferation of jurkat cells induced by ouabain]
• [New option for gene-targeting vector construction Red/ET recombination]
• [Surgery for BPH with impaired detrusor contractility: a report of 12 cases]