Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis.

Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis. Research Abstract Details 

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Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis. Abstract Text:

Chapman M Wright,Glenn D Christman,Ann M Snellinger,Murray V Johnston,Eugene G Mueller,

Two proposed mechanisms for 4-thiouridine generation share key cysteine persulfide and disulfide intermediates, and indirect evidence of their existence has been previously reported; chemical trapping and mass spectrometry have now provided direct and definitive evidence of these key intermediates.

Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis. Publishing Authors By Initials

CM Wright,GD Christman,AM Snellinger,MV Johnston,EG Mueller,

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Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Chemical communications (Cambridge, England)

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Page Numbers: 3104-6

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ISSN: 1359-7345

DAY: 14

MONTH: 06

YEAR: 2006

Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis.

AFFILIATION: Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.

Country: England

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MEDLINETA: Chem Commun (Camb)

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