[Direct enantioseparation of pantoprazole sodium by high performance liquid chromatography on teicoplanin-bonded chiral stationary phase]

[Direct enantioseparation of pantoprazole sodium by high performance liquid chromatography on teicoplanin-bonded chiral stationary phase] Research Abstract Details 

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[Direct enantioseparation of pantoprazole sodium by high performance liquid chromatography on teicoplanin-bonded chiral stationary phase] Abstract Text:

Guosheng Ding,Anna Tang,Junde Wang,Runzi Cong,Jianmin Bao,

Teicoplanin-bonded chiral stationary phase was prepared and used for the direct chiral separation of racemic pantoprazole sodium by reversed-phase high performance liquid chromatography (HPLC). The influences of organic modifiers, the composition of mobile phase, the flow rate and column temperature on enantioseparation were studied. It was found that methanol was preferred than acetonitrile when used as organic modifier. With the increase of column temperature, chiral solutes were less retained and the separation factor value decreased indicating that lower temperature was better for the enantioseparation. Better resolution was obtained at lower flow rates as a result of minimization of the resistance of mass transfer. Based on these experimental data, the chiral HPLC method for the analysis of pantoprazole sodium on prepared chiral column (150 mm x 4.6 mm i. d., 5 microm) was established with simplicity and good reproducibility, by using methanol-water (35 : 65, v/v) as mobile phase at a flow rate of 0.6 mL/min and 20 degrees C.

[Direct enantioseparation of pantoprazole sodium by high performance liquid chromatography on teicoplanin-bonded chiral stationary phase] Publishing Authors By Initials

G Ding,A Tang,J Wang,R Cong,J Bao,

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[Direct enantioseparation of pantoprazole sodium by high performance liquid chromatography on teicoplanin-bonded chiral stationary phase] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Se pu = Chinese journal of chromatography / Zhongg

VOLUME: 24

Page Numbers: 46-8

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ISSN: 1000-8713

DAY: 10

MONTH: Jan

YEAR: 2006

[Direct enantioseparation of pantoprazole sodium by high performance liquid chromatography on teicoplanin-bonded chiral stationary phase] Information

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LANGUAGE: chi

NlmUniqueID: 9424804

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Grant and Affiliation Information for [Direct enantioseparation of pantoprazole sodium by high performance liquid chromatography on teicoplanin-bonded chiral stationary phase]

AFFILIATION: College of Pharmaceutical and Technology, Tianjin University, Tianjin 300072, China. dgs@dicp.ac.cn

Country: China

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MEDLINETA: Se Pu

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