Direct determination of metformin in urine by adsorptive catalytic square-wave voltammetry.

Direct determination of metformin in urine by adsorptive catalytic square-wave voltammetry. Research Abstract Details 

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Direct determination of metformin in urine by adsorptive catalytic square-wave voltammetry. Abstract Text:

S?awomira Skrzypek,Valentin Mirceski,Witold Ciesielski,Adam Soko?owski,Robert Zakrzewski,S?awomira Skrzypek,Valentin Mirceski,Witold Ciesielski,Adam Soko?owski,Robert Zakrzewski,S?awomira Skrzypek,Valentin Mirceski,Witold Ciesielski,Adam Soko?owski,Robert Zakrzewski,

A new adsorptive catalytic voltammetric method for voltammetric determination of metformin based on the catalytic hydrogen evolution reaction at a hanging mercury drop electrode was developed. The electrode reaction was analyzed under conditions of linear sweep voltammetry (LSV), differential pulse voltammetry (DPV) and Osteryoung-type square-wave voltammetry (SWV). The peak current depends on pH of the medium, concentration and chemical composition of the buffer solution, and instrumental parameters. The optimal conditions for quantitative determination were obtained in an acetate buffer at pH 4.7. The voltammetric procedure was characterized with respect to the repeatability, precision and the recovery. The detection and quantification limits were found to be 1.8 x 10(-8) and 5.9 x 10(-8) mol l(-1) for SWV, 3.2 x 10(-8) and 1.0 x 10(-7) mol l(-1) for DPV, and 7.7 x 10(-8) and 2.5 x 10(-7) mol l(-1) for LSV, respectively. The SW voltammetric method, as the most sensitive one, was applied for determination of metformin in human urine. The voltammetric method has been validated by using HPLC with UV detection.

Direct determination of metformin in urine by adsorptive catalytic square-wave voltammetry. Publishing Authors By Initials

S Skrzypek,V Mirceski,W Ciesielski,A Soko?owski,R Zakrzewski,S Skrzypek,V Mirceski,W Ciesielski,A Soko?owski,R Zakrzewski,S Skrzypek,V Mirceski,W Ciesielski,A Soko?owski,R Zakrzewski,

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Direct determination of metformin in urine by adsorptive catalytic square-wave voltammetry. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of pharmaceutical and biomedical analysis

VOLUME: 45

Page Numbers: 275-81

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ISSN: 0731-7085

DAY: 12

MONTH: 07

YEAR: 2007

Direct determination of metformin in urine by adsorptive catalytic square-wave voltammetry. Information

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LANGUAGE: eng

NlmUniqueID: 8309336

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Grant and Affiliation Information for Direct determination of metformin in urine by adsorptive catalytic square-wave voltammetry.

AFFILIATION: Department of Instrumental Analysis, University of ?ód?, Pomorska 163, 90-236 ?ód?, Poland. skrzpek@uni.lodz.pl

Country: England

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MEDLINETA: J Pharm Biomed Anal

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