Direct Comparison of Transcardiac Increase in Brain Natriuretic Peptide (BNP) and N-Terminal ProBNP and Prognosis in Patients With Chronic Heart Failure.

Direct Comparison of Transcardiac Increase in Brain Natriuretic Peptide (BNP) and N-Terminal ProBNP and Prognosis in Patients With Chronic Heart Failure. Research Abstract Details 

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Direct Comparison of Transcardiac Increase in Brain Natriuretic Peptide (BNP) and N-Terminal ProBNP and Prognosis in Patients With Chronic Heart Failure. Abstract Text:

Takayoshi Tsutamoto,Hiroshi Sakai,Keizo Nishiyama,Toshinari Tanaka,Masanori Fujii,Takashi Yamamoto,Minoru Horie,Takayoshi Tsutamoto,Hiroshi Sakai,Keizo Nishiyama,Toshinari Tanaka,Masanori Fujii,Takashi Yamamoto,Minoru Horie,Takayoshi Tsutamoto,Hiroshi Sakai,Keizo Nishiyama,Toshinari Tanaka,Masanori Fujii,Takashi Yamamoto,Minoru Horie,

Background No previous study has compared the transcardiac gradient of cardiac natriuretic peptides and prognosis. Methods and Results To compare the prognostic value of the transcardiac increase in brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) in patients with chronic heart failure (CHF), the hemodynamic parameters and plasma levels of BNP and NT-proBNP were measured in the aortic root (AO) and coronary sinus (CS) in 353 consecutive patients with CHF. During a median follow-up of 2.8 years, 35 patients died. The molar ratio of (CS-AO) NT-proBNP to (CS-AO) BNP correlated with hemodynamic abnormalities and it was significantly higher in non-survivors than in survivors (median value =0.702 vs 0.437, respectively; p=0.0009), suggesting that NT-proBNP is superior to BNP in terms of transcardiac increase. After adjustment for clinical variables associated with CHF, including hemodynamics and an estimated glomerular filtration rate, it was found that only the plasma NT-proBNP level was an independent prognostic predictor, even after considering the transcardiac increases in BNP and NT-proBNP. Conclusion These findings suggest that the transcardiac gradient of NT-proBNP to BNP molar ratio increases with the severity of left ventricular dysfunction, and that plasma NT-proBNP level may be more useful than BNP for evaluating the prognosis of patients with CHF. (Circ J 2007; 71: 1873 - 1878).

Direct Comparison of Transcardiac Increase in Brain Natriuretic Peptide (BNP) and N-Terminal ProBNP and Prognosis in Patients With Chronic Heart Failure. Publishing Authors By Initials

T Tsutamoto,H Sakai,K Nishiyama,T Tanaka,M Fujii,T Yamamoto,M Horie,T Tsutamoto,H Sakai,K Nishiyama,T Tanaka,M Fujii,T Yamamoto,M Horie,T Tsutamoto,H Sakai,K Nishiyama,T Tanaka,M Fujii,T Yamamoto,M Horie,

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Direct Comparison of Transcardiac Increase in Brain Natriuretic Peptide (BNP) and N-Terminal ProBNP and Prognosis in Patients With Chronic Heart Failure. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Circulation journal : official journal of the Japa

VOLUME: 71

Page Numbers: 1873-8

Journal Abbreviation: Circ. J.

ISSN: 1346-9843

DAY: 26

MONTH: Dec

YEAR: 2007

Direct Comparison of Transcardiac Increase in Brain Natriuretic Peptide (BNP) and N-Terminal ProBNP and Prognosis in Patients With Chronic Heart Failure. Information

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LANGUAGE: eng

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AFFILIATION: Cardiovascular and Respiratory Medicine, Shiga University of Medical Science.

Country: Japan

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