Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema.

Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema. Research Abstract Details 

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Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema. Abstract Text:

James Brian Byrd,Karine Touzin,Saba Sile,James V Gainer,Chang Yu,John Nadeau,Albert Adam,Nancy J Brown,James Brian Byrd,Karine Touzin,Saba Sile,James V Gainer,Chang Yu,John Nadeau,Albert Adam,Nancy J Brown,

Angioedema is a potentially life-threatening adverse effect of angiotensin-converting enzyme inhibitors. Bradykinin and substance P, substrates of angiotensin-converting enzyme, increase vascular permeability and cause tissue edema in animals. Studies indicate that amino-terminal degradation of these peptides, by aminopeptidase P and dipeptidyl peptidase IV, may be impaired in individuals with angiotensin-converting enzyme inhibitor-associated angioedema. This case-control study tested the hypothesis that dipeptidyl peptidase IV activity and antigen are decreased in sera of patients with a history of angiotensin-converting enzyme inhibitor-associated angioedema. Fifty subjects with a history of angiotensin-converting enzyme inhibitor-associated angioedema and 176 angiotensin-converting enzyme inhibitor-exposed control subjects were ascertained. Sera were assayed for angiotensin-converting enzyme activity, aminopeptidase P activity, aminopeptidase N activity, dipeptidyl peptidase IV activity, and antigen and the ex vivo degradation half-lives of bradykinin, des-Arg(9)-bradykinin, and substance P in a subset. The prevalence of smoking was increased and of diabetes decreased in case versus control subjects. Overall, dipeptidyl peptidase IV activity (26.6+/-7.8 versus 29.6+/-7.3 nmol/mL per minute; P=0.026) and antigen (465.8+/-260.8 versus 563.1+/-208.6 ng/mL; P=0.017) were decreased in sera from individuals with angiotensin-converting enzyme inhibitor-associated angioedema compared with angiotensin-converting enzyme inhibitor-exposed control subjects without angioedema. Dipeptidyl peptidase IV activity (21.5+/-4.9 versus 29.8+/-6.7 nmol/mL per minute; P=0.001) and antigen (354.4+/-124.7 versus 559.8+/-163.2 ng/mL; P=0.003) were decreased in sera from cases collected during angiotensin-converting enzyme inhibition but not in the absence of angiotensin-converting enzyme inhibition. The degradation half-life of substance P correlated inversely with dipeptidyl peptidase IV antigen during angiotensin-converting enzyme inhibition. Environmental or genetic factors that reduce dipeptidyl peptidase IV activity may predispose individuals to angioedema.

Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema. Publishing Authors By Initials

JB Byrd,K Touzin,S Sile,JV Gainer,C Yu,J Nadeau,A Adam,NJ Brown,JB Byrd,K Touzin,S Sile,JV Gainer,C Yu,J Nadeau,A Adam,NJ Brown,

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Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Hypertension

VOLUME: 51

Page Numbers: 141-7

Journal Abbreviation: Hypertension

ISSN: 1524-4563

DAY: 19

MONTH: 11

YEAR: 2007

Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema. Information

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LANGUAGE: eng

NlmUniqueID: 7906255

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Grant and Affiliation Information for Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema.

AFFILIATION: Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01-HL079184

ACRONYM: HL

MEDLINETA: Hypertension

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