Dip-pen nanolithography of reactive alkoxysilanes on glass.

Dip-pen nanolithography of reactive alkoxysilanes on glass. Research Abstract Details 

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Dip-pen nanolithography of reactive alkoxysilanes on glass. Abstract Text:

Hyungil Jung,Rajan Kulkarni,C Patrick Collier,

The use of organofunctional silane chemistry is a flexible and general method for immobilizing biomolecules on silicon oxide surfaces, including fabricating DNA, small-molecule, and protein microarrays. The biggest hurdle in employing dip-pen nanolithography (DPN) for extending this general approach to the nanoscopic domain is the tendency of trialkoxy- and trichlorosilanes to rapidly polymerize due to hydrolysis reactions. The control of the local water concentration between the substrate surface and the scanning AFM tip is critical, both to the physical and chemical processes involved in DPN writing and to the ability to form well-defined thin layers of reactive silanes without extensive polymerization induced disorder. We found that we could control the degree of polymerization through careful choice of the alkoxysilane used as the "ink" for DPN and through control of the relative humidity during inking and writing with the coated AFM tip. As a proof-of-principle, we demonstrate that areas patterned with an alkoxysilane on glass with DPN are functional for subsequent immobilization of fluorescently labeled streptavidin via covalent attachment of biotin. This preliminary result sets the stage for the ability to capture proteins in their fully hydrated state from buffered solution, by molecular recognition onto previously written reactive nanoscopic regions on oxidized silicon and glass.

Dip-pen nanolithography of reactive alkoxysilanes on glass. Publishing Authors By Initials

H Jung,R Kulkarni,CP Collier,

For similar inorganic chemicals: silicon compounds: silanes research abstracts see: inorganic chemicals: silicon compounds: silanes research

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Dip-pen nanolithography of reactive alkoxysilanes on glass. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 125

Page Numbers: 12096-7

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 8

MONTH: Oct

YEAR: 2003

Dip-pen nanolithography of reactive alkoxysilanes on glass. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Dip-pen nanolithography of reactive alkoxysilanes on glass. Keywords Mesh Terms:

KEYWORDS: Silanes

MESH TERMS: chemistry

Chemical & Substance for Abstract: Dip-pen nanolithography of reactive alkoxysilanes on glass. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Dip-pen nanolithography of reactive alkoxysilanes on glass.

AFFILIATION: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

Country: United States

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MEDLINETA: J Am Chem Soc

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