Dioctatin A is a strong inhibitor of aflatoxin production by Aspergillus parasiticus.

Dioctatin A is a strong inhibitor of aflatoxin production by Aspergillus parasiticus. Research Abstract Details 

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Dioctatin A is a strong inhibitor of aflatoxin production by Aspergillus parasiticus. Abstract Text:

Tomoya Yoshinari,Tetsuo Akiyama,Keita Nakamura,Tatsuhiko Kondo,Yoshikazu Takahashi,Yasuhiko Muraoka,Yoshiaki Nonomura,Hiromichi Nagasawa,Shohei Sakuda,

Dioctatin A (DotA), a metabolite of Streptomyces, is known to be an inhibitor of human dipeptidyl aminopeptidase II. Here, it was found that DotA strongly inhibited aflatoxin production by Aspergillus parasiticus, with an IC50 value of 4.0 microM. The mycelial growth of the fungus was not affected by the addition of DotA at a concentration of 50 microM, but inhibition of conidiation was observed at the same concentration. DotA inhibited production of norsolorinic acid, an early biosynthetic intermediate of aflatoxin, and it strongly reduced the mRNA levels of genes encoding aflatoxin biosynthetic enzymes, and significantly decreased the mRNA level of aflR, which encodes a key regulatory protein for aflatoxin biosynthesis. In addition to these genes, the mRNA level of brlA, which encodes a conidiation-specific transcription factor, was also reduced by the addition of DotA. It was also found that DotA dramatically enhanced kojic acid production by the fungus. Furthermore, DotA inhibited production of sterigmatocystin, which is a toxic aflatoxin biosynthetic intermediate, and it also inhibited conidiation in Aspergillus nidulans. These results indicate that DotA has pleiotropic effects on regulatory mechanisms of fungal secondary metabolite production and differentiation, leading to inhibition of aflatoxin production.

Dioctatin A is a strong inhibitor of aflatoxin production by Aspergillus parasiticus. Publishing Authors By Initials

T Yoshinari,T Akiyama,K Nakamura,T Kondo,Y Takahashi,Y Muraoka,Y Nonomura,H Nagasawa,S Sakuda,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Dioctatin A is a strong inhibitor of aflatoxin production by Aspergillus parasiticus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Microbiology (Reading, England)

VOLUME: 153

Page Numbers: 2774-80

Journal Abbreviation: Microbiology (Reading, Engl.)

ISSN: 1350-0872

DAY: 27

MONTH: Aug

YEAR: 2007

Dioctatin A is a strong inhibitor of aflatoxin production by Aspergillus parasiticus. Information

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LANGUAGE: eng

NlmUniqueID: 9430468

Dioctatin A is a strong inhibitor of aflatoxin production by Aspergillus parasiticus. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: Dioctatin A is a strong inhibitor of aflatoxin production by Aspergillus parasiticus. Information

Substance Name: norsolorinic acid

Registry Number: 78371-59-2

Grant and Affiliation Information for Dioctatin A is a strong inhibitor of aflatoxin production by Aspergillus parasiticus.

AFFILIATION: Department of Applied Biological Chemistry, The University of Tokyo, Tokyo 113-8657, Japan.

Country: England

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MEDLINETA: Microbiology

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