Dinuclear lanthanum(III) complex for efficient hydrolysis of RNA.

Dinuclear lanthanum(III) complex for efficient hydrolysis of RNA. Research Abstract Details 

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Dinuclear lanthanum(III) complex for efficient hydrolysis of RNA. Abstract Text:

M Yashiro,A Ishikubo,M Komiyama,

A dinuclear La3+ complex hydrolyzes the phosphodiester bond in diribonucleotides efficiently under mild conditions. The rate of hydrolysis is remarkably accelerated on the complex formation between La3+ and TPHP (TPHP = N,N,N',N'-tetrakis [(2-pyridyl)methyl]-2-hydroxy-1,3-diaminopropane), and the highest activity is attained when the dinuclear structure is formed. The half-life of ApA hydrolysis by the dinuclear La3+ complex (1 mM) is 350 s, whereas that by the free La3+ ion (1 mM) is 23,000 s at pH 7.2 and 50 degrees C. The dinuclear La3+ complex is promising as a catalytic center of artificial nucleases.

Dinuclear lanthanum(III) complex for efficient hydrolysis of RNA. Publishing Authors By Initials

M Yashiro,A Ishikubo,M Komiyama,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna research

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Dinuclear lanthanum(III) complex for efficient hydrolysis of RNA. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 120

Page Numbers: 1067-9

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Dec

YEAR: 1996

Dinuclear lanthanum(III) complex for efficient hydrolysis of RNA. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Dinuclear lanthanum(III) complex for efficient hydrolysis of RNA. Keywords Mesh Terms:

KEYWORDS: RNA

MESH TERMS: metabolism

Chemical & Substance for Abstract: Dinuclear lanthanum(III) complex for efficient hydrolysis of RNA. Information

Substance Name: Lanthanum

Registry Number: 7439-91-0

Grant and Affiliation Information for Dinuclear lanthanum(III) complex for efficient hydrolysis of RNA.

AFFILIATION: Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo.

Country: JAPAN

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MEDLINETA: J Biochem

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