Diminished potential for B-lymphoid differentiation after murine leukemia virus infection in vivo and in EML hematopoietic progenitor cells.

Diminished potential for B-lymphoid differentiation after murine leukemia virus infection in vivo and in EML hematopoietic progenitor cells. Research Abstract Details 

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Diminished potential for B-lymphoid differentiation after murine leukemia virus infection in vivo and in EML hematopoietic progenitor cells. Abstract Text:

Samantha L Finstad,Naomi Rosenberg,Laura S Levy,

Infection with a recombinant murine-feline gammaretrovirus, MoFe2, or with the parent virus, Moloney murine leukemia virus, caused significant reduction in B-lymphoid differentiation of bone marrow at 2 to 8 weeks postinfection. The suppression was selective, in that myeloid potential was significantly increased by infection. Analysis of cell surface markers and immunoglobulin H gene rearrangements in an in vitro model demonstrated normal B-lymphoid differentiation after infection but significantly reduced viability of differentiating cells. This reduction in viability may confer a selective advantage on undifferentiated lymphoid progenitors in the bone marrow of gammaretrovirus-infected animals and thereby contribute to the establishment of a premalignant state.

Diminished potential for B-lymphoid differentiation after murine leukemia virus infection in vivo and in EML hematopoietic progenitor cells. Publishing Authors By Initials

SL Finstad,N Rosenberg,LS Levy,

For similar virus diseases: tumor virus infections research abstracts see: virus diseases: tumor virus infections research

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Diminished potential for B-lymphoid differentiation after murine leukemia virus infection in vivo and in EML hematopoietic progenitor cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of virology

VOLUME: 81

Page Numbers: 7274-9

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 11

MONTH: 04

YEAR: 2007

Diminished potential for B-lymphoid differentiation after murine leukemia virus infection in vivo and in EML hematopoietic progenitor cells. Information

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LANGUAGE: eng

NlmUniqueID: 113724

Diminished potential for B-lymphoid differentiation after murine leukemia virus infection in vivo and in EML hematopoietic progenitor cells. Keywords Mesh Terms:

KEYWORDS: Tumor Virus Infections

MESH TERMS: pathology

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Grant and Affiliation Information for Diminished potential for B-lymphoid differentiation after murine leukemia virus infection in vivo and in EML hematopoietic progenitor cells.

AFFILIATION: Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Avenue SL-38, New Orleans, LA 70112, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA83823

ACRONYM: CA

MEDLINETA: J Virol

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