Islets of Langerhans

Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.

Glucagon-Secreting Cells Research

Insulin-Secreting Cells Research

Pancreatic Polypeptide-Secreting Cells Research

Abstracts

- Aspects of the structure and function of the pancreatic B-cell in diabetes mellitus.

- Beta-cell function and diabetic control in insulin dependent diabetes melletus. Beta-cell function, as evaluated from plasma C-peptide measurements, is found in all insulin dependent diabetic patients the first months of disease and in...

- Pancreatic islet cells and ascorbic acid in guinea pigs.

- [Chemical elimination of the alpha cells of islands of Langerhans.]

- [Effects of p-aminobenzene-sulfamido-isopropylthiodiazol on glycemia, on the structure of the islands of Langerhans and on the metabolism of normal or diabetic animals.]

- [Responses of alpha and beta cells of the pancreas to arginine during cardiopulmonary bypass]

- [Ultrastructural findings of beta granules in the endocrine pancreas of the sand rat, Psammomys obesus] The ultrastructural study with morphometric research was realized on beta granules of B cells of pancreatic islets of the normoglycemic Sand Rat, Psammomys...

- [Will type I diabetes mellitus be treated with immunosuppressive drugs in the future?] Even if the pathogenesis of type-I (insulin-dependent) diabetes mellitus is still not clarified in every detail, there is general agreement that this form of...