Diffusion tensor imaging in children with fetal alcohol spectrum disorders.

Diffusion tensor imaging in children with fetal alcohol spectrum disorders. Research Abstract Details 

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Diffusion tensor imaging in children with fetal alcohol spectrum disorders. Abstract Text:

Jeffrey R Wozniak,Bryon A Mueller,Pi-Nian Chang,Ryan L Muetzel,Lydia Caros,Kelvin O Lim,

BACKGROUND: Prenatal alcohol exposure, which is associated with macrostructural brain abnormalities, neurocognitive deficits, and behavioral disturbances, is characterized as fetal alcohol syndrome (FAS) in severe cases. The only published study thus far using diffusion tensor imaging (DTI) showed microstructural abnormalities in patients with FAS. The current study investigated whether similar abnormalities are present in less severely affected, prenatally exposed patients who did not display all of the typical FAS physical stigmata. METHODS: Subjects included 14 children, ages 10 to 13, with fetal alcohol spectrum disorders (FASD) and 13 matched controls. Cases with full-criteria FAS, mental retardation, or microcephaly were excluded. Subjects underwent MRI scans including DTI. RESULTS: Although cases with microcephaly were excluded, there was a trend toward smaller total cerebral volume in the FASD group (p=0.057, Cohen's d effect size =0.73). Subjects with FASD had greater mean diffusivity (MD) in the isthmus of the corpus callosum than controls (p=0.013, effect size =1.05), suggesting microstructural abnormalities in this region. There were no group differences in 5 other regions of the corpus callosum. Correlations between MD in the isthmus and facial dysmorphology were nonsignificant. CONCLUSIONS: These results suggest that even relatively mild forms of fetal alcohol exposure may be associated with microstructural abnormalities in the posterior corpus callosum that are detectable with DTI.

Diffusion tensor imaging in children with fetal alcohol spectrum disorders. Publishing Authors By Initials

JR Wozniak,BA Mueller,PN Chang,RL Muetzel,L Caros,KO Lim,

For similar female urogenital diseases and pregnancy complications: pregnancy complications: prenatal injuries: prenatal exposure delayed effects research abstracts see: female urogenital diseases and pregnancy complications: pregnancy complications: prenatal injuries: prenatal exposure delayed effects research

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Diffusion tensor imaging in children with fetal alcohol spectrum disorders. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Alcoholism, clinical and experimental research

VOLUME: 30

Page Numbers: 1799-806

Journal Abbreviation: Alcohol. Clin. Exp. Res.

ISSN: 0145-6008

DAY: 3

MONTH: Oct

YEAR: 2006

Diffusion tensor imaging in children with fetal alcohol spectrum disorders. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7707242

Diffusion tensor imaging in children with fetal alcohol spectrum disorders. Keywords Mesh Terms:

KEYWORDS: Prenatal Exposure Delayed Effects

MESH TERMS: pathology

Chemical & Substance for Abstract: Diffusion tensor imaging in children with fetal alcohol spectrum disorders. Information

Substance Name: Ethanol

Registry Number: 64-17-5

Grant and Affiliation Information for Diffusion tensor imaging in children with fetal alcohol spectrum disorders.

AFFILIATION: Department of Psychiatry, University of Minnesota, Minneapolis, MN, 55454, USA. jwozniak@umn.edu

Country: England

AGENCY: United States NCRR

GRANT: MO1-RR00400

ACRONYM: RR

MEDLINETA: Alcohol Clin Exp Res

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