Diffusion anisotropy in the corpus callosum.

Diffusion anisotropy in the corpus callosum. Research Abstract Details 

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Diffusion anisotropy in the corpus callosum. Abstract Text:

Neeraj B Chepuri,Yi-Fen Yen,Jonathan H Burdette,Hong Li,Dixon M Moody,Joseph A Maldjian,

BACKGROUND AND PURPOSE: The corpus callosum is a heterogeneous white-matter tract that connects the cerebral hemispheres. The purpose of this investigation was to study its microstructural architecture in normal human adult brains by using diffusion tensor imaging (DTI). METHODS: Two hundred consecutive patients referred for brain MR imaging underwent additional DTI with a high gradient field strength applied in six directions. Forty-two patients met the following inclusion criteria: 1) normal brain and 2) age greater than 18 years. Anisotropy maps were generated, and regions of interest were drawn around specified regions within the corpus callosum. Results were stratified by sex and age. In addition, available histologic specimens of the corpus callosum from cadaver brains were analyzed with conventional and specialized vascular staining. RESULTS: Anisotropy values in the various regions of the corpus callosum differed significantly. Average values of the anisotropy index for the genu, body, and splenium of the corpus callosum were 0.400, 0.456, and 0.539, respectively. The differences between these values are statistically significant (P <.01). Increased anisotropy was present in posterior areas in both sexes and in all three age groups examined. CONCLUSION: The results of this investigation show a statistically significant increase in anisotropy of the corpus callosum in its more posterior portions compared with its more anterior portions across sex and age groups. Although the microstructural etiology for this apparent increase in anisotropy is unclear, a number of possible mechanisms are presented.

Diffusion anisotropy in the corpus callosum. Publishing Authors By Initials

NB Chepuri,YF Yen,JH Burdette,H Li,DM Moody,JA Maldjian,

For similar natural sciences: weights and measures: reference values research abstracts see: natural sciences: weights and measures: reference values research

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Diffusion anisotropy in the corpus callosum. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AJNR. American journal of neuroradiology

VOLUME: 23

Page Numbers: 803-8

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ISSN: 0195-6108

DAY: 14

MONTH: May

YEAR: 2002

Diffusion anisotropy in the corpus callosum. Information

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LANGUAGE: eng

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Diffusion anisotropy in the corpus callosum. Keywords Mesh Terms:

KEYWORDS: Reference Values

MESH TERMS: methods

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Grant and Affiliation Information for Diffusion anisotropy in the corpus callosum.

AFFILIATION: Department of Radiology, Wake Forest University School of Medicine, Bowman Gray Campus, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

Country: United States

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MEDLINETA: AJNR Am J Neuroradiol

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