Diffuse optical imaging of the whole head.

Diffuse optical imaging of the whole head. Research Abstract Details 

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Diffuse optical imaging of the whole head. Abstract Text:

Maria Angela Franceschini,Danny K Joseph,Theodore J Huppert,Solomon G Diamond,David A Boas,

Near-Infrared Spectroscopy (NIRS) and diffuse optical imaging (DOI) are increasingly used to detect hemodynamic changes in the cerebral cortex induced by brain activity. Until recently, the small number of optodes in NIRS instruments has hampered measurement of optical signals from diverse brain regions. Our new DOI system has 32 detectors and 32 sources; by arranging them in a specific pattern, we can cover most of the adult head. With the increased number of optodes, we can collect optical data from prefrontal, sensorimotor, and visual cortices in both hemispheres simultaneously. We describe the system and report system characterization measurements on phantoms as well as on human subjects at rest and during visual, motor, and cognitive stimulation. Taking advantage of the system's larger number of sources and detectors, we explored the spatiotemporal patterns of physiological signals during rest. These physiological signals, arising from cardiac, respiratory, and blood-pressure modulations, interfere with measurement of the hemodynamic response to brain stimulation. Whole-head optical measurements, in addition to providing maps of multiple brain regions' responses to brain activation, will enable better understandings of the physiological signals, ultimately leading to better signal processing algorithms to distinguish physiological signal clutter from brain activation signals.

Diffuse optical imaging of the whole head. Publishing Authors By Initials

MA Franceschini,DK Joseph,TJ Huppert,SG Diamond,DA Boas,

For similar investigative techniques: chemistry, analytical: photometry: spectrophotometry: spectrophotometry, infrared research abstracts see: investigative techniques: chemistry, analytical: photometry: spectrophotometry: spectrophotometry, infrared research

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Diffuse optical imaging of the whole head. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomedical optics

VOLUME: 11

Page Numbers: 054007

Journal Abbreviation:

ISSN: 1083-3668

DAY: 3

MONTH: 12

YEAR: 2007

Diffuse optical imaging of the whole head. Information

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LANGUAGE: eng

NlmUniqueID: 9605853

Diffuse optical imaging of the whole head. Keywords Mesh Terms:

KEYWORDS: Spectrophotometry, Infrared

MESH TERMS: methods

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Grant and Affiliation Information for Diffuse optical imaging of the whole head.

AFFILIATION: Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, 13th Street, Bldg. 149 (RM 2301), Charlestown, Massachusetts 02129, USA. mari@nmr.mgh.harvard.edu

Country: United States

AGENCY: United States NCI

GRANT: T32-CA09502

ACRONYM: CA

MEDLINETA: J Biomed Opt

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