Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia.

Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia. Research Abstract Details 

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Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia. Abstract Text:

James R Goldenring,Sachiyo Nomura,

Gastric cancer in humans arises in the setting of oxyntic atrophy (parietal cell loss) and attendant hyperplastic and metaplastic lineage changes within the gastric mucosa. Helicobacter infection in mice and humans leads to spasmolytic polypeptide-expressing metaplasia (SPEM). In a number of mouse models, SPEM arises after oxyntic atrophy. In mice treated with the parietal cell toxic protonophore DMP-777, SPEM appears to arise from the transdifferentiation of chief cells. These results support the concept that intrinsic mucosal influences regulate and modulate the appearance of gastric metaplasia even in the absence of significant inflammation, whereas chronic inflammation is required for the further neoplastic transition.

Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia. Publishing Authors By Initials

JR Goldenring,S Nomura,

For similar neoplasms: neoplasms by site: digestive system neoplasms: gastrointestinal neoplasms: stomach neoplasms research abstracts see: neoplasms: neoplasms by site: digestive system neoplasms: gastrointestinal neoplasms: stomach neoplasms research

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Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia. Journal Published:

PUBLICATION TYPE: Review

Journal: American journal of physiology. Gastrointestinal a

VOLUME: 291

Page Numbers: G999-1004

Journal Abbreviation: Am. J. Physiol. Gastrointest.

ISSN: 0193-1857

DAY: 3

MONTH: Dec

YEAR: 2006

Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia. Information

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LANGUAGE: eng

NlmUniqueID: 100901227

Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia. Keywords Mesh Terms:

KEYWORDS: Stomach Neoplasms

MESH TERMS: pathology

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Grant and Affiliation Information for Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia.

AFFILIATION: Nashville Department of Veterans Affairs Medical Center, Nashville, TN, USA. jim.goldenring@vanderbilt.edu

Country: United States

AGENCY: United States NCI

GRANT: 1-P50-CA-95103

ACRONYM: CA

MEDLINETA: Am J Physiol Gastrointest Live

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