Differentiation of human embryonic stem cells into bipotent mesenchymal stem cells.

Differentiation of human embryonic stem cells into bipotent mesenchymal stem cells. Research Abstract Details 

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Differentiation of human embryonic stem cells into bipotent mesenchymal stem cells. Abstract Text:

Emmanuel N Olivier,Anne C Rybicki,Eric E Bouhassira,Emmanuel N Olivier,Anne C Rybicki,Eric E Bouhassira,

Mesenchymal stem cells (MSCs) are multipotent progenitors that can be found in many connective tissues, including fat, bone, cartilage, and muscle. We report here a method to reproducibly differentiate human embryonic stem cells (hESCs) into MSCs that does not require the use of any feeder layer. The cells obtained with this procedure are morphologically similar to bone marrow MSCs, are contact-inhibited, can be grown in culture for about 20 to 25 passages, have an immunophenotype similar to bone marrow MSCs (negative for CD34 and CD45 and positive for CD13, CD44, CD71, CD73, CD105, CD166, human leukocyte antigen [HLA]-ABC, and stage-specific embryonic antigen [SSEA]-4), can differentiate into osteocytes and adipocytes, and can be used as feeder cells to support the growth of undifferentiated hESCs. The ability to produce MSCs from hESCs should prove useful to produce large amounts of genetically identical and genetically modifiable MSCs that can be used to study the biology of MSCs and for therapeutic applications.

Differentiation of human embryonic stem cells into bipotent mesenchymal stem cells. Publishing Authors By Initials

EN Olivier,AC Rybicki,EE Bouhassira,EN Olivier,AC Rybicki,EE Bouhassira,

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Differentiation of human embryonic stem cells into bipotent mesenchymal stem cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Stem cells (Dayton, Ohio)

VOLUME: 24

Page Numbers: 1914-22

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ISSN: 1066-5099

DAY: 27

MONTH: 04

YEAR: 2006

Differentiation of human embryonic stem cells into bipotent mesenchymal stem cells. Information

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LANGUAGE: eng

NlmUniqueID: 9304532

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Grant and Affiliation Information for Differentiation of human embryonic stem cells into bipotent mesenchymal stem cells.

AFFILIATION: Department of Medicine, Division of Hematology, Einstein Center for Human Embryonic Stem Cell Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

Country: United States

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MEDLINETA: Stem Cells

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